食管腺癌中EGF的表达及临床意义和预后的关系  

Expression of EGF in esophageal adenocarcinoma and its clinical significance

作　　者：赵得富 梁少杰 张克[1] 李德冰 路遥 段会娟 王红岩[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《现代预防医学》2017年第23期4377-4380,共4页Modern Preventive Medicine

摘　　要：目的研究讨论EGF在食管腺癌的表达情况及其与临床特征、预后的关系。方法运用免疫组织化学方法研究EGF在50例食管腺癌标本中的表达水平并分析其与患者临床病理特征及预后的相关性。结果 EGF在50例食管腺癌、癌旁组织中的阳性率分别为64%和22%。Logistic回归模型进行多因素分析,结果显示临床分期和淋巴结转移是EGF表达相关的独立因素(P<0.05)本组研究三年生存率59.6%,五年生存率42.5%,预后单因素分析:有淋巴结转移的患者比无淋巴结转移的5年生存率短(P=0.010),临床分期高的比临床分期低的5年生存率短(P=0.005),EGF阳性的患者比EGF阴性患者生存时间短(P=0.041),分化程度低的比分化程度高的生存时间短(P=0.006),而与性别,年龄,肿瘤浸润程度,肿瘤大小有无烟酒史无明显相关性。结论 EGF在食管腺癌中表达增高,且该表达与食管腺癌的浸润、发展、转移呈现一种相关性,淋巴结转移、临床分期、分化程度是食管腺癌患者预后的主要因素。Objective To study the EGF expression in esophageal carcinoma and its relationship with clinical features and prognosis. Methods The expression levels of EGF in 50 samples of patients with esophageal adenocarcinoma were detected using immunohistochemical method and its correlation with clinical pathological characteristics and prognosis was analyzed. Results In 50 cases of esophageal adenocarcinoma tissue and tissue adjacent to carcinoma, the positive rates of EGF were 64% and 22% respectively. Multiple - factor analysis with Logistic regression model showed that the clinical stage and lymph node metastasis were independent factors of EGF expression （ P 〈 0.05 ） The three - year survival rate was 59.6% and 5 - year survivai＇rate was 42.5%. The single factor analysis of prognosis： 5 -year survival rate of patients with lymph node metastasis was shorter than that in patients without lymph node metastasis （P = 0. 010）, and 5 -year survival rate in the high clinical stage was shorter than that in low clinical stage （ P = 0. 005 ）, The survival time of patients with EGF positive was shorter than that of patients with EGF negative （P = 0.041 ）. The survival time of patients with low degree of differentiation was shorter than that of cases with high degree of differentiation （P = 0. 006）. Gender, age, degree of tumor infiltration, tumor size and having a smoke -free wine history had no obvious correlation with prognosis. Conclusion EGF expression in esophageal adenocarcinoma increases and shows a correlation with invasion of the esophageal adenocarcinoma, development and transfer. Lymph node metastasis, clinical stage, differentiation degree are the main factors of the prognosis of patients with esophageal adenocarcinoma.

关 键 词：食管癌 腺癌 表皮生长因子 预后生存时间 

分 类 号：R181.32[医药卫生—流行病学]