软脉煎联合常规西药治疗颈动脉粥样硬化的临床观察  

Clinical Observation of “Ruanmai Decoction” Combined with Conventional Western Medicine in the Treatment of Carotid Atherosclerosis

作　　者：杜文婷[1] 王臻楠[1] 顾耘[1] 高东雯[1] 孙卫华[1] 龚路[1] 徐辉[1] 潘露茜[1] 韩素静[1] 孙国珺[1] 许若玢 林宇栋[1] 高爽[1] 王嘉宜 吴建文[1] 

机构地区：[1]上海中医药大学附属龙华医院老年科,上海200032

出　　处：《上海中医药大学学报》2017年第6期24-28,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫计委科研基金资助项目(2014LP089A);上海市科委科研计划项目(14401972505);国家中医药管理局全国名老中医药专家传承工作室建设项目--"林水淼全国名老中医传承工作室"项目

摘　　要：目的:评价中药复方软脉煎联合西医常规疗法治疗肾精亏虚型颈动脉粥样硬化的临床疗效。方法:将102例肾精亏虚型颈动脉粥样硬化患者随机分为治疗组和对照组,每组各51例。对照组患者给予西医常规治疗,治疗组患者在西医常规治疗同时加用软脉煎口服治疗,疗程均为6个月。治疗前后评价并比较两组患者的中医证候积分,检测两组患者的血脂指标[包括三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、极低密度脂蛋白胆固醇(VLDL-C)]和血清同型半胱氨酸(Hcy)水平。结果:治疗后,治疗组患者的中医证候积分较治疗前明显降低(P<0.01),对照组患者的中医证候积分明显升高(P<0.05),治疗组患者的中医证候积分显著低于对照组(P<0.05,P<0.01);治疗后,治疗组患者的TG、TC、LDL-C水平较治疗前降低(P<0.05),对照组患者的TC、HDL-C水平较治疗前降低(P<0.05),而VLDL-C水平较治疗前升高(P<0.05),治疗组患者的TG、LDL-C水平显著低于对照组(P<0.05);治疗后,治疗组患者的Hcy水平较治疗前降低(P<0.05),对照组患者的Hcy水平较治疗前升高(P<0.05),治疗组患者的Hcy水平显著低于对照组(P<0.05)。结论:中药复方软脉煎联合西医常规疗法治疗颈动脉粥样硬化,能够改善患者的中医证候和血脂指标,降低患者的Hcy水平。Objective： To evaluate the clinical efficacy of ＂Ruanmai Decoction＂ combined with conventional western medicine in the treatment of carotid atherosclerosis with syndrome of kidney essence deficiency. Methods： A total of 102 patients of carotid atherosclerosis with syndrome of kidney essence deficiency were randomly divided into the treatment group and control group, 51 cases in each group. The patients in the control group were treated with the conventional western medicine and the patients in the treatment group were treated with ＂Ruanmai Decoction＂ combined with the conventional western medicine, with a course of 6 months. The Chinese medical syndrome scores of both groups were evaluated and compared before and after treatment, and the levels of serum homocysteine （Hey） and the blood lipid indexes including triacylglycerol （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） and very low density lipoprotein cholesterol （VLDL-C） were detected. Results： After treatment, the Chinese medical syndrome scores of the treatment group were significantly decreased （P 〈0.01 ） , the scores of the control group were obviously increased （ P 〈 0.05 ）, and the scores of the treatment group were significantly lower than those of the control group （ P 〈0.05 ,P 〈0.01 ）. After treatment, the levels ofTG, TC and LDL-C in the treatment group were decreased （ P 〈0.05） ; the levels of TC and HDL-C in the control group were decreased （ P 〈 0.05 ） and the level of VLDL-C was increased （ P 〈 0.05 ） ; the levels of TG and LDL-C in the treatment group were significantly lower than those in the control group （ P 〈 0.05 ）. After treatment, the level of Hcy in the treatment group was decreased （ P 〈 0.05 ）, the level of Hcy in the control group was increased （ P 〈 0.05 ）, and the level of Hcy in the treatment group was significantly lower than that in the control group （ P 〈 0.05

关 键 词：颈动脉粥样硬化 软脉煎 补肾法 

分 类 号：R543.4[医药卫生—心血管疾病]