抗抑郁中药的药理研究进展  

Research Progress on Pharmacology of Traditional Chinese Medicine Against Depression

作　　者：张磊阳 蒋健[1] 贺敏[1] 李玥[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中国实验方剂学杂志》2017年第24期224-234,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市进一步加快中医药事业发展三年行动计划项目(ZY3-CCCX-3-2007)

摘　　要：抑郁症是一种严重的精神疾病,危害人类身心健康。药物治疗是应对抑郁症的主要治疗手段。目前临床上常用的抗抑郁药,大多是化学合成的、以单胺类神经递质为靶点的药物,普遍存在副作用大、起效缓慢、药价高和疗效差等缺点。而中药治疗抑郁症历史悠久,为从中寻找出疗效较好、副作用较小的抗抑郁药提供了可能。具有抗抑郁作用的中药复方主要有疏肝解郁类、养心安神类及理气祛痰与活血化瘀类;单味中药及活性成分根据饮片分类主要有补益类、理气活血类、安神与平肝息风类、清热化湿类及解表止咳类。中药抗抑郁药理学研究的新知见、新成果或对传统辨证论治临证思维及用药习惯带来深刻影响。本文先从与抑郁症发病相关的解剖结构及生化指标两方面进行简要叙述,再对近几年来具有抗抑郁作用的中药进行归纳。拟为中药抗抑郁药物的研发提供参考。Depression is one kind of mental diseases and endangers human health seriously. Until now,Drug therapy has been the main treatment of depression. At present,most commonly-prescribed antidepressants are chemically synthesized,and most of which are monoamine neurotransmitters modulators. These drugs have many disadvantages,such as remarkable side effects,slow onset,expensive prices and poor treatment outcome. The traditional Chinese medicine（ TCM） has a long history in treating depression,thus providing an alternative to antidepressants with better efficacy and less side effects. Chinese herbal compounds which have antidepressant effects,could be classified by mechanism as follows-relieving the depressed liver,calming the mind by nourishing the heart,regulating vital energy and dispelling phlegm,invigorating blood circulation to dissipate blood stasis.According to the source of TCM decoction pieces,single herbs and active ingredients can be divided into the following catagories-tonics,regulating Qi and promoting the circulation of blood,tranquilization and calming liver wind,clearing heat and removing dampness,relieving exterior syndrome and cough. The new research results and achievements of antidepressant pharmacological research will exert a profound impact on the idea of traditional syndrome differentiation and treatment as well as the habits in medicine employment. In this paper,anatomical structure and biochemical indicators are briefly discussed,and then TCM which have antidepressant effects,in recent years are reviewed. This review aims to provide reference to the research and development of herbal antidepressants.

关 键 词：抑郁症 抗抑郁中药 药理 实验研究 

分 类 号：R285.5[医药卫生—中药学]