丙型肝炎患者RNA载量和肝功能指标及血细胞参数的相关性分析  

Analysis of the correlation between HCV-RNA and liver function and blood indexes in patients with HCV

作　　者：刘文俊[1] 杨霞芳[1] 钟秋连[1] 黄春晖 

机构地区：[1]广西壮族自治区人民医院检验科,南宁530021

出　　处：《中国临床新医学》2017年第12期1168-1171,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的探讨丙型肝炎病毒(hepatitis C virus,HCV)患者RNA载量与肝功能指标及血细胞参数之间的相关性。方法收集该院2013~2015年收治的丙型肝炎患者165例,并选择健康体检人群40名,用实时荧光定量PCR仪检测HCV-RNA载量,全自动生化仪检测肝功能,全自动血球仪检测血细胞参数,并进行统计学分析。结果丙型肝炎组血浆清蛋白(ALB)、白细胞计数(WBC)、中性粒细胞计数(NEUT)、粒细胞比例(NEUTR)水平均低于对照组,淋巴细胞比例(LYR)及谷丙转氨酶(ALT)高于对照组,差异有统计学意义(P<0.01)。不同RNA载量丙型肝炎患者ALB、血细胞参数水平差异无统计学意义(P>0.05),患者ALT水平随RNA载量的升高而升高,差异有统计学意义(P<0.05)。结论丙型肝炎患者ALT水平与RNA载量相关,ALB及血细胞检测与RNA载量无显著相关。Objective To analyze the correlation between hepatitis C virus RNA（HCV-RNA） and liver function and blood indexes in patients with hepatitis C virus（HCV）.Methods The blood samples were collected from 165 patients with HCV and 40 healthy people, whose serum quantity HCV-RNA was detected by PCR-flurescence and whose liver function and blood analysis were detected by automation instrument. The results were compared between the two different groups of the people.Results The levels of albumin（ALB）, leukocytes counts（WBC）, neutrophils counts（NEUT） and neutrophil ratio（NEUTR） in the HCV patients were significantly lower than those in the healthy people, lymphocytes ratio（LYR） and the level of alanine（ALT） in the HCV patients was significantly higher than that in the healthy people（P〈0.01）. There were no significant differences in the levels of ALB and blood indexes between different groups of the people with different quantities of HCV-RNA（P〉0.05）. The level of ALT increased with the quantity of HCV-RNA rising（P〈0.05）.Conclusion The level of ALT is correlated with the quantity of HCV-RNA, while ALB and blood indexes are not correlated with the quantity of HCV-RNA.

关 键 词：丙型肝炎 肝功能 血细胞参数 RNA载量 

分 类 号：R512.63[医药卫生—内科学]