右美托咪定对重度颅脑创伤大鼠脑水肿程度的影响  

Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury

作　　者：李正超[1] 钱传云[1] 吴海鹰[1] 张玮[1] 夏婧[1] 

机构地区：[1]昆明医科大学第一附属医院急诊医学科、EICU,云南昆明650032

出　　处：《昆明医科大学学报》2017年第11期40-44,共5页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2014J043)

摘　　要：目的研究右美托咪定对重度颅脑创伤(TBI)后大鼠大脑水肿程度的影响.方法制作SD大鼠颅脑创伤模型,并使用右美托咪定进行治疗干预,观察72 h内大鼠神经功能损害程度、脑组织含水量和BBB通透性的变化.结果不同组TBI大鼠各时间点NSS评分:主体内效应差异有统计学意义(P=0.041),主体间效应差异有统计学意义(P<0.001);不同组TBI大鼠各时间点脑组织含水量:主体内效应差异有统计学意义(P=0.032),主体间效应差异有统计学意义(P<0.001);神经功能评分和脑水肿程度具有相关性(r=0.61,P<0.001)结论 TBI大鼠脑水肿高峰为TBI后24 h;TBI大鼠在损伤早期使用右美托咪定镇静治可降低BBB通透性及减轻大鼠脑组织水肿,从而促进神经功能恢复.Objective To study the effect of dexmedetomidine on brain edema in rats with severe traumatic brain injury（TBI）.Methods SD rat traumatic brain injury model was established and was treated with dexmedetomidine.The changes of neurological impairment,brain water content and BBB permeability were observed within 72 hours after injury.Results The NSS score of different TBI rats in different groups：the difference of internal effect was statistically significant（P=0.041）,and the difference between subjects was statistically significant（P0.001）.The water content of the brain tissue in different groups of TBI rats was statistically significant（P=0.032）,and the difference between subjects was statistically significant（P0.001）.The correlation was found between neurological score and cerebral edema degree（r=0.61,P0.001）.Conclusions TBI rat cerebral edema peaks at 24 h after TBI.Dexmedetomidine can reduce BBB permeability and reduce the edema of TBI rats in the early stage of injury,thereby promoting the recovery of nerve function.

关 键 词：颅脑创伤脑水肿 右美托咪定 AQP4 

分 类 号：R541.7[医药卫生—心血管疾病]