冠心病介入诊疗术后NGAL对造影剂肾病预测价值的相关性  

Correlation between NGAL and Predictive Value of Contrast Induced Nephropathy after Interventional Treatment for Coronary Heart Disease

作　　者：苗文清[1] 王宇[1] 杨俊[1] 张义红[1] 段会仙[1] 赵仲文 汪艳 

机构地区：[1]昆明市第一人民医院,云南昆明650011

出　　处：《昆明医科大学学报》2017年第12期102-106,共5页Journal of Kunming Medical University

基　　金：北京力生心血管健康基金会领航基金资助项目(LHJJ20158821)

摘　　要：目的探讨血/尿NGAL浓度对造影剂肾病预测价值的相关性研究.方法顺序入组2016年10月至12月于昆明市第一人民医院行冠脉介入诊断和\或治疗的88例患者,以发生CIN的病例作为CIN组(7例);在未发生CIN的病例作为非CIN组(81例),共计88例.分别收集各组临床基线资料.采用ELISA法测定血/尿NGAL浓度.用SPSS进行统计分析.结果 CIN组及非CIN组术前、术后2 h、术后24 h血NGAL水平差异有统计学意义(P<0.05).术后2 h及术后24 h尿NGAL水平差异有统计学意义(P<0.05).CIN组及非CIN组术前、术后2 h、术后24 h尿NGAL水平差异有统计学意义(P<0.05).血NGAL24h术后的ROC曲线下面积(AUC)为0.743,诊断造影剂肾病的界值为4.114,敏感度和特异度分别为85.7%和64.2%;尿NAGL 24 h术后的ROC曲线下面积(AUC)为0.961,诊断造影剂肾病的界值为4.798时,敏感度和特异度分别为100%和91.4%.结论发现血/尿NGAL术后24h浓度可以作为预测造影剂肾病的指标.Objective To investigate the correlation between blood / urine NGAL concentration andpredictive value of contrast induced nephropathy. Methods A total of 88 patients who underwent coronaryintervention and / or treatment were enrolled in our hospital from October to December in 2016. The patients with CINwere treated as CIN （7 cases ） . In cases where CIN did not occur As non-CIN group （81 cases ）, a total of 89cases. The clinical baseline data were collected from each group. The concentration of NGAL in blood / urine wasmeasured by ELISA. Statistical analysis was performed using SPSS20.0. Results The results showed that thedifference of NGAL level between CIN group and non - CIN group was statistically significant （ P〈0.05） . Therewas significant difference in urine NGAL level between 2 h and 24 h after operation （ P〈 0.05） . There wassignificant difference in urinary NGAL level between the CIN group and the non-CIN group （ P〈0.05） . In thepresent study, the area under the ROC curve （AUC） was 0.743, the diagnostic value of renal disease was4.114, and the sensitivity and specificity were 85.7% and 64.2% respectively. In this study, ROC The area underthe curve （ AUC） was 0.961,and the sensitivity and specificity were 100% and 91.4%,respectively, when thediagnostic value of contrast medium nephropathy was 4.798. Conclusion Blood / urine NGAL 24h after coronary intervention can be used as a predictor of contrast nephropathy.

关 键 词：NGAL 冠状动脉粥样硬化性心脏病 造影剂肾病 

分 类 号：R541[医药卫生—心血管疾病]