rs671和rs1801157基因多态性与云南汉族人群心肌梗死的易感性分析  

Correlation analysis of rs671 and rs1801157 polymorphisms and myocardial infarction in Han population of Yunnan province

作　　者：刘萍[1] 光雪峰[2] 张富荣[1] 何亮[1] 杨麦巧 王芳[1] 

机构地区：[1]昆明医科大学附属延安医院麻醉科,云南昆明650051 [2]昆明医科大学附属延安医院心内科,云南昆明650051

出　　处：《中国现代医学杂志》2017年第30期36-40,共5页China Journal of Modern Medicine

基　　金：云南省应用基础研究计划(昆医联合专项)(No:2013FZ288)

摘　　要：目的对云南高海拔地区汉族人群rs671和rs1801157单核苷酸多态性(SNP)进行分析,探讨其与心肌梗死(MI)易感性的关系。方法 Sequenom Mass Array系统基因分型方法对500例云南高海拔地区汉族MI患者和350例对照组患者rs671和rs1801157的基因多态性进行检测,结合患者CAD/MI主要独立危险因素(性别、年龄、高血压、糖尿病、脂质浓度、肥胖程度、烟酒史及家族史等),分析MI与SNP变化之间的潜在关联性。结果 rs671和rs1801157基因型在MI组和对照组中达到遗传平衡(P>0.05)。MI组中rs671AA、AG及A等位基因频率与rs1801157的GG、GA及G等位基因均高于对照组,而rs671的GG基因型和rs1801157的AA频率、A等位基因低于对照组(P<0.05)。加性模型下,rs671 A等位基因能增加MI的患病风险[^OR=2.57(95%CI:1.96,3.37)P<0.05],而rs1801157基因型G等位基因能增加MI的患病风险[^OR=2.68(95%CI:1.84,3.15)P<0.05];在显性模型下,rs671 A等位基因能增加MI的患病风险[^OR=3.69(95%CI:2.68,5.08)P<0.05];在隐性模型下,rs671和rs1801157与MI无相关,^OR=3.86(95%CI:0.88,17.03,P=0.074)和2.06(95%CI:0.68,4.89,P=0.12)。在非饮酒患者中rs671 A等位基因能增加MI的患病风险[^OR=1.27(95%CI:1.05,2.93)P=0.032];在饮酒患者中rs671A等位基因不能增加MI的患病风险^OR=1.58(95%CI:0.84,1.87,P=0.36),在饮酒与否的患者中rs1801157均不增加MI的患病风险。结论 rs671和rs1801157位点的多态性变异与MI遗传易感性相关,rs671A和rs1801157等位基因能增加MI患者的患病风险。Objective To investigate the potential correlation of single nucleotide polymorphism （SNP） ofas well as and myocardial infarction （MI） in a group of Chinese Han population from Yunnanprovince. Methods Sequenom MassArray system genotyping was utilized to identify the polymorphisms ofand in 500 MI patients as well as 350 healthy volunteers. The potential association between MIand SNPs was analyzed in addition to consideration of major independent risk factors such as gender, age,hypertension, diabetes, lipid concentration, obesity, smoking, drinking and family history. Results Genotypes ofand were equally distributed in MI group and control group. Frequency of AA,A and AG genotype in of MI group was higher while GG genotype was lower significantly than that in controlgroup （P〈 0.05）. Frequency of GG, GA and G genotype in of MI group was higher while AA andA genotype was significantly lower than that in control group （P〈 0.05）. In additive model,A allele ofand G allele of rs1801157 increased risk of MI with OR equal to 2.57 （95% CI： 1.96, 3.37, 〈 0.05）. Indominant model,A allele of increased risk of MI with OR equal to 3.69 （95% CI： 2.68, 5.08, P〈0.05）. In recessive model, no significant correlation between as well as and MI was observedwith OR equal to 3.86 （95% CI： 0.88, 17.03, P= 0.074）. A allele of increased risk of MI in non-drinking patients with OR equal to 1.27 （95% CI： 1.05, 2.93, P= 0.032）, while no such association wasobserved in drinking patients with OR equal to 1.58 （95% CI： 0.84, 1.87, = 0.36）. No correlation wasfounded between drinking and polymorphism as MI risk factors. Conclusions Polymorphic variationof and is closely associated with susceptibility to MI in Chinese Han population of Yunnanprovince. Alleles of and are genetic risk factors of MI.

关 键 词：心肌梗死 rs671 基因多态性 遗传易感性 

分 类 号：R542.22[医药卫生—心血管疾病]