头孢西丁预防肛肠外科患者术后切口感染的效果研究  

Effect of cefoxitin on prevention of incision infections in surgery patients from department of anus & intestine surgery

作　　者：何莹[1] 金纯[1] 诸葛林敏[1] 傅凌雪[1] 王奕英 赵蔚蔚 

机构地区：[1]温州医科大学附属第二医院肛肠外科,浙江温州325000

出　　处：《中华医院感染学杂志》2017年第23期5384-5386,5394,共4页Chinese Journal of Nosocomiology

摘　　要：目的观察头孢西丁预防肛肠外科手术患者术后切口感染的效果,以降低肛肠外科手术患者切口感染率。方法选择2016年1月-2017年1月医院收治的120例肛肠外科手术患者为研究对象,采用数字随机表法分为对照组和试验组,每组60例;对照组按照肛肠外科手术临床路径于围术期采取相应措施预防术后切口感染,试验组在对照组预防切口措施基础上,再于术前、术后给予头孢西丁预防术后切口感染,分析比较两组术后一个月切口愈合、感染率、药物不良反应、术后住院时间等情况。结果术后1个月,试验组发生术后感染1例,感染率1.67%,对照组发生术后感染4例,感染率6.67%,试验组感染率低于对照组(P<0.05);试验组术后住院时间低于对照组(P<0.05);对照组大肠埃希菌构成比高于试验组(P<0.05)。结论头孢西丁能有效预防肛肠外科患者术后切口感染,且不增加患者药物不良反应率,缩短患者术后住院时间,对肛肠手术患者具有一定的临床价值。OBJECTIVE To observe the effect of cefoxitin on prevention of postoperative incision infections in patients from department of anus intestine surgery,so as to reduce the infection rate of incision of surgical patients in department of anus intestine surgery.METHODS A total of 120 cases of patients from department of anus intestine surgery treated in the hospital from Jan.2016 to Jan.2017 were selected as the objects of study.The patients were divided into control group and observation group by digital random table,with 60 cases in each group.Patients in control group were taken corresponding measures for prevention of postoperative incision infections according to the clinical pathway in the perioperative period of department of anus intestine surgery surgery,and in observation group were given cefoxitin before and after surgery to prevent postoperative incision infections on the basis of control group.The incision healing,infection rate,adverse drug reactions and postoperative hospital stay were analyzed and compared between the two groups.RESULTS One month after operation,there was to 1 cases of patients had postoperative infection in observation group,with the infection rate of 1.67%,and 4 cases of postoperative infections occurred in observation group,with the infection rate of 6.67%,and the infection rate of observation group was significantly lower than that of control group（P0.05）.The hospitalization time after operation of observation group was significantly lower than that of control group（P0.05）.The constituent ratio of Escherichia coli in control group was significantly higher than that in observation group（P 0.05）.CONCLUSIONCefoxitin can effectively prevent postoperative incision infection in patients from department of anus intestine surgery,and does not increase the adverse drug reaction rate in patients,can shorten the hospitalization time of patients after surgery,which has certain clinical value to the patients with anorectal surgery.

关 键 词：头孢西丁 肛肠外科手术 术后切口感染 药物不良反应 病原菌 

分 类 号：R619.3[医药卫生—外科学]