针刺干预慢性疼痛突触可塑性变化:“疼痛记忆”的机制探讨  

Advances in Acupuncture Mechanism Research on the Changes of Synaptic Plasticity:“Pain Memory”for Chronic Pain

作　　者：杨一玲[1] 黄键澎 蒋丽[1] 刘健华[1] 

机构地区：[1]广州中医药大学第二临床医学院,广州510000

出　　处：《针刺研究》2017年第6期547-551,共5页Acupuncture Research

基　　金：国家自然科学基金(No.81673888);国家自然科学青年基金(No.81403461)

摘　　要：研究表明,有关疼痛和记忆的神经网络之间有着较多的共同结构,构成疼痛网络核心的主要结构同样也是记忆网络的一部分。慢性疼痛反复发作导致外周异位冲动长期持续性兴奋,引起神经活动依赖的突触结构和功能发生变化而产生长时程增强效应,即诱导中枢神经系统产生"疼痛记忆"。针刺作为慢性疼痛治疗的有效手段之一,可通过刺激躯体外周对脊髓背角、海马、扣带回等"疼痛记忆"相关区域产生镇痛作用,其机制包括阿片肽介导的镇痛效应、抑制胶质细胞的活化以及促进脑源性神经营养因子的表达等。本文就针刺治疗慢性疼痛的国内外最新文献研究,对"疼痛记忆"的形成和针刺干预慢性疼痛突触可塑性变化机制进行综述。Previous studies have shown that there are many common structures between the neural network of pain and memory, and the main structure in the pain network is also part of the memory network. Chronic pain is characterized by recurrent attacks and is associated with persistent ectopic impulse, which causes changes in synaptic structure and function based on nerve activity. These changes may induce long-term potentiation of synaptic transmission, and ultimately lead to changes in the central nervous system to produce ＂pain memory＂. Acupuncture is an effective method in treating chronic pain. It has been proven that acupuncture can affect the spinal cord dorsal horn, hippocampus, cingulate gyrus and other related areas. The possible mecha- nisms of action include opioid-induced analgesia, activation of glial cells, and the expression of brain derived neurotrophic factor （BDNF）. In this study, we systematically review the brain structures, stage of ＂pain memory＂ and the mechanisms of acupuncture on synaptic plasticity in chronic pain.

关 键 词：慢性疼痛 针刺 可塑性 记忆 综述 

分 类 号：R245.9[医药卫生—针灸推拿学]