高血压患者血清血管紧张素转化酶水平与心房颤动的相关性分析  

The Correlation Between Serum Angiotensin Converting Enzyme Level and Atrial Fibrillation in Patients with Hypertension

作　　者：张如森 

机构地区：[1]福州市第一医院心血管内科,福建福州350009

出　　处：《临床医学工程》2017年第12期1739-1740,共2页Clinical Medicine & Engineering

摘　　要：目的分析高血压患者血清血管紧张素转化酶(ACE)水平和心房颤动(AF)发生的关系。方法选择2014年1月至2016年12月我院高血压住院患者145例,依据临床诊断将患者分为未合并AF的对照组71例和合并AF的观察组74例。比较两组患者的性别、年龄、BMI、血压,以及高敏C反应蛋白(hs-CRP)、血清脑钠肽(BNP)、左房内径和左心室射血分数(LVEF)、ACE水平,采用Logistic回归分析观察差异因素与AF发生的关系。结果两组患者的性别、年龄和BMI无统计学差异(P>0.05),观察组的收缩压和舒张压显著高于对照组(P<0.05)。两组患者的LVEF水平无统计学差异(P>0.05),观察组的hsCRP、BNP、左房内径和ACE水平均显著高于对照组,差异具有统计学意义(P<0.05)。Logistic回归分析表明左房内径扩大(OR=0.953,P=0.042)和ACE升高(OR=1.072,P=0.002)为AF发生的独立危险因素。结论高血压患者的血清ACE升高和左房内径扩大为AF发生的独立危险因素。Objective To analyze the correlation between serum angiotensin converting enzyme （ACE） level and atrial fibrillation （AF） in hypertensive patients. Methods A total of 145 cases ofinpatients with hypertension in our hospital from January 2014 to December 2016 were selected. According to the clinical diagnosis, 71 patients who did not complicated with AF were set as the control group, and 74 patients complicated with AF were set as the observation group. The gender, age, BMI, blood pressure, high sensitivity C-reactive protein 0as-CRP）, serum brain natriuretic peptide （BNP）, left atrial diameter, left ventricular ejection fraction （LVEF） and ACE levels were compared between two groups. The relationships between the differential factors and the occurrence of AF were analyzed by Logistic regression analysis. Results No significant difference was found between two groups in the sex, age or BMI （P〉0.05）; The systolic blood pressure and diastolic blood pressure of observation group were higher than those of control group （P〈0.05）. No significant difference was found between two groups in the level of LVEF （P〉0.05）; The levels of hs-CRP, BNP, left atrial diameter and ACE of observation group were significantly higher those in control group （P〈0.05）. Logistic regression analysis showed that left atrial diameter enlargement （OR = 0.953, P= 0.042） and ACE elevation （OR = 1.072, P= 0.002） were the independent risk factors of AF. Conclusions Both serum ACE elevation and left atrial diameter enlargement are the independent risk factors for the occurrence of AF in hypertensive patients.

关 键 词：高血压 血清血管紧张素转化酶 心房颤动 

分 类 号：R541.3[医药卫生—心血管疾病]