孕前及早孕期孕激素相关治疗与发生妊娠期糖尿病的关系探讨  

作　　者：高波[1] 李红梅[1] 蒋玲祥[1] 赵国强[1] 

机构地区：[1]浙江省绍兴市妇幼保健院,312000

出　　处：《浙江临床医学》2018年第1期79-80,共2页Zhejiang Clinical Medical Journal

基　　金：浙江省人口计划生育科研课题（2014KYB363）

摘　　要：目的探讨孕前及早孕期孕激素相关治疗与发生妊娠期糖尿病（GDM）的关系。方法2016年1月至12ill中孕期确诊的GDM孕妇，孕前3个月至孕后3个月使用舍孕激素相关药物或器械者107例列入观察组，有单个GDM高危因素者182例列入GDM对照组，同时随机选取无GDM高危因素者182例列入正常对照组，三组孕妇在早孕期及中孕期OGTT检查时分别采血测定血清孕酮进行比较分析。结果早孕期观察组分别与GDM对照组、正常对照组比较孕酮明显升高（P〈0．05），GDM对照组与正常对照组比较孕酮无显著差异（P〉0．05）；中孕期OGTT检查时观察组与正常对照组比较、GDM对照组与正常对照组比较孕酮明显升高（P〈0.05），观察组与GDM对照组比较孕酮差异无统计学意义（P〉0．05）。结论孕前及早孕期孕激素相关治疗与GDM发生有一定相关性，可作为GDM的一个独立高危因素。Objective To investigate the relationship between progesterone related therapy in pre-pregnancy and early pregnancy and the occurrence of gestational diabetes mellitus. Methods The pregnant women in our hospital were screened form January 2016 to December 2016 in 12 months who were diagnosed with GDM in the second trimester, 107 cases with progestin related drugs or devices were counted, included in the observation group, 182 cases with single high risk factor of GDM were included in the GDM control group, randomly selected without GDM risk factors of 182 cases were included in the normal control group.Three groups of pregnant women were compared and analyzed by blood serum progesterone respectively in the first trimester and OGTT when in the second trimester. Results In the first trimester, progesterone of the observation group was increased significantly compared with the GDM control group and normal control group （ P〈0.05 ） , had no significant difference between the GDM group and the normal control group （P〉0.05） .In the second trimester, progesterone of the observation group compared with normal control group and the GDM control group compared with the normal control group were increased significantly （ P〈0.05 ） , the observation group compared with the GDM control group had no significant difference （ P〉0.05 ） . Conclusion Progesterone related therapy in pre-pregnancy and early pregnancy is related to the occurrence of GDM, and can be an independent high risk factor of GDM.

关 键 词：孕激素 妊娠期糖尿病 高危因素 

分 类 号：R714.256[医药卫生—妇产科学]