莫西沙星临床应用的不良反应及用药安全性分析  

Adverse Reactions of Moxifloxacin and its Safety

作　　者：张远晖[1] 

机构地区：[1]厦门大学附属第一医院杏林分院药学部,福建厦门361000

出　　处：《中国卫生标准管理》2017年第27期107-109,共3页China Health Standard Management

摘　　要：目的分析莫西沙星不良反应的特点,探讨其临床用药的安全性问题。方法选取我院肺科2015年12月—2016年12月使用莫西沙星(拜复乐)后产生不良反应的60例患者临床资料,对其进行回顾性分析,并且从药物结构、相互作用等多个方面探讨莫西沙星的用药安全性问题。结果在60例不良反应中,有48例以注射方式给药,12例以口服方式给药。其不良反应累及系统/器官为:皮肤损害19例、中枢神经系统损伤18例、心血管系统损伤13例、横纹肌溶解症6例、其他损伤4例。结论临床需要对莫西沙星用药安全性加以重视,对其不良反应的发生提高警惕,并定期进行监测与分析,减少莫西沙星使用中发生的安全性问题。Objective To analyze the characteristics of moxifloxacin adverse reactions and explore the safety of clinical drug use. Methods The clinical data of 60 patients with moxifloxacin from December 2015 to December 2016 were retrospectively analyzed. The drug safety of moxifloxaein was discussed from the aspects of drug structure and interaction. Results Of the 60 cases adverse reactions, 48 cases were administered by injection and 12 cases were administered orally. The adverse reactions involving the system / organ were： skin damage in 19 cases, central nervous system injury in 18 cases, cardiovascular system injury in 13 cases, rhabdomyolysis in 6 cases, and other injuries in 4 cases. Conclusion The clinical need to pay attention to the safety of moxifloxacin, to guard against the occurrence of adverse reactions, and regular monitoring and analysis to reduce the safety problems occurred during the use of moxifloxacin.

关 键 词：莫西沙星 不良反应 安全性 

分 类 号：R969[医药卫生—药理学]