疏风祛湿止痒药浴法治疗尿毒症瘙痒症疗效观察  

Curative Effect Observation of Applying Dispelling Wind and Dampness Itching Medicated Bath Therapy for Uremic Prutitus

作　　者：余燕娜[1] 王亮亮 吴兴波[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《新中医》2017年第12期64-66,共3页New Chinese Medicine

基　　金：广东省中医药局课题(20161137)

摘　　要：目的:观察疏风祛湿止痒药浴法治疗尿毒症瘙痒症(UP)的临床疗效。方法:将30例UP患者随机分为治疗组与对照组各15例,2组均进行常规血液透析治疗及其它基础治疗,对照组患者接受普通清水洗浴,治疗组给予疏风祛湿止痒药浴,治疗前及治疗2周后分别填写生活质量调查问卷(SF-36)和Dirk R Kuypers皮肤瘙痒评分问卷,比较2组治疗前后生活质量及实验室指标变化情况。结果:治疗后,治疗组患者SF-36各维度得分均升高,分别与治疗前比较,差异均有统计学意义(P<0.05);与对照组比较,差异均有统计学意义(P<0.05)。治疗后,治疗组瘙痒症状评分下降,与治疗前比较,差异有统计学意义(P<0.05);且治疗组瘙痒评分低于对照组,差异有统计学意义(P<0.05)。2组血磷、i PTH、β2微球蛋白、C-反应蛋白水平均下降,前后比较,差异均有统计学意义(P<0.05);且治疗组上述指标下降更明显,与对照组比较,差异有统计学意义(P<0.05)。2组患者血钙、血钾、血清白蛋白(Alb)水平治疗前后比较,差异均无统计学意义(P>0.05)。结论:疏风祛湿止痒药浴法可改善UP患者的生活质量及临床症状,值得临床运用。Objective： To observe clinical effect of dispelling wind and dampness itching medicated bath therapy for uremic pruritus（UP）. Methods： Divided 30 UP patients into the treatment group and control group randomly, 15 cases in each group. Both groups received routine hemodialysis and other basic treatments. The control group additionally received clean water bath, while the treatment group additionally received dispelling wind and dampness itching medicated bath. Both groups filled in life quality questionnaires（SF-36） and Dirk R Kuypers pruritus score questionnaires before treatment and after two weeks treatment. Compared the changes of life qualities and laboratory indexes of both groups before and after treatment. Results： After treatment, all dimension scores of patients in the treatment group were increased when compared with those before treatment, differences being significant（P〈0.05）; compared with the control group, the differences being significant（P〈0.05）. After treatment, pruritus symptoms score in the treatment group was decreased when compared with that before treatment, and the score in the treatment group was lower than that in the control group, the differences being significant （P 〈0.05）. Levels of serum phosphorus, iPTH, 152 microglobulin and C-reactive protein in both groups were decreased when compared with those before treatment, differences being significant（P〈0.05）; and the decrease of above indexes in the treatment group were more evident than those in the control group, differences being significant（P〈0.05）. No significance was found in the comparison of levels of blood calcium, serum potassium and AIb between the two groups（P〉0.05）. Conclusion： Dispelling wind and dampness itching medicated bath therapy can effectively improve quality of life and clinical symptoms of UP patients, which deserves clinical application.

关 键 词：尿毒症瘙痒症 药浴法 疏风祛湿止痒 瘙痒症状评分 生活质量调查问卷(SF-36) 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]