健脾补肾汤治疗继发性肾性骨质疏松症临床观察  

Clinical Observation of Jianpi Bushen Tang for Secondary Renovascular Osteoporosis

作　　者：李建浩 陆伟峰 王国樑 

机构地区：[1]绍兴市柯桥区齐贤医院中西医结合骨科,浙江绍兴312065

出　　处：《新中医》2017年第12期86-88,共3页New Chinese Medicine

摘　　要：目的:观察健脾补肾汤治疗继发性肾性骨质疏松症的临床疗效。方法:将纳入观察的300例患者随机分为2组各150例。对照组在治疗原发病的基础上采用鲑鱼降钙素及阿仑膦酸钠治疗;观察组在对照组治疗方案的基础上加用健脾补肾汤治疗。2组均治疗12周。治疗结束后比较2组患者疼痛缓解程度、骨密度变化、骨性标志物、新发骨折率、25-羟维生素D的差异及临床疗效。结果:治疗后,2组疼痛视觉模拟评分(VAS)、25-羟维生素D、骨代谢标志物OC分别与治疗前比较,差异均有统计学意义(P<0.05);且2组间比较,差异均有统计学意义(P<0.05)。治疗后,观察组L_1~L_4腰椎、股骨颈的骨密度分别与治疗前比较,差异均有统计学意义(P<0.05)。2组间L_1~L_4腰椎、股骨颈的骨密度比较,差异均有统计学意义(P<0.05)。总有效率对照组73.33%,观察组93.33%,2组比较,差异有统计学意义(P<0.05)。2组新发骨折发生率比较,差异有统计学意义(P<0.05)。结论:继发性肾性骨质疏松症在基础治疗的基础上采用健脾补肾汤可有效减轻患者的疼痛,提高患者的骨密度及临床疗效。Objective： To observe the clinical effect of jianpi bushen tang for secondary renovascular osteoporosis. Methods： Divided 300 cases of patients enrolled in the observation into two groups randomly, 150 cases in each group. Both groups received salmon calcitonin and alendronate sodium based on the treatment for primary disease, while the observation group additionally received jianpi bushen tang. Both groups were treated for 12 weeks. After treatment, respectively compared pain relief, changes of bone mineral density （BMD）, bone marker, the occurrence rate of new fractures, and 25-hydroxyvitamin D in the two groups with those before treatment. Results： After treatment, VAS of pain, 25- hydroxyvitamin D and osteocalcin （OC） as an bone turnover marker in both groups were compared with those before treatment, differences being significant （P 〈 0.05）, and the intergroup comparison showed significance in differences （P 〈 0.05）. After treatment, BMD of L1 -L4 lumbar vertebra and femoral neck were compared with those before treatment, differences being significant（P 〈 0.05）, and the intergroup comparison of BMD of L1 ~ L4 lumbar vertebra and femoral neck displayed significance in differences （P 〈 0.05）. The total effective rate was 73.33% in the control group and 93.33% in the observation group, the difference being significant （P 〈 0.05）. The occurrence rate of new fractures in both groups was compared, the difference being significant（P 〈 0.05）. Conclusion： Additional application of jianpi bushen tang based on the treatment for secondary renovascular osteoporosis can significantly release pain in patients, increase bone mineral density and enhance the clinical effect.

关 键 词：继发性肾性骨质疏松症 健脾补肾汤 骨密度 25-羟维生素D 骨代谢标志物OC 

分 类 号：R589.5[医药卫生—内分泌]