系统性红斑狼疮患儿自身抗体及免疫球蛋白和补体分析  

Analysis of autoantibody, immunoglobulin and complement in children with systemic lupus erythematosus

作　　者：赖琴[1] 刘瑜[1] 

机构地区：[1]重庆医科大学附属儿童医院检验科,重庆400010

出　　处：《医学检验与临床》2017年第5期25-27,共3页Medical Laboratory Science and Clinics

摘　　要：目的：探讨系统性红斑狼疮患儿自身抗体及免疫球蛋白和补体水平.方法：收集2014年2月~2016年1月我院系统性红斑狼疮患儿,表现为皮疹、 发热及关节痛等,定义为研究组.对照组为我院健康体检的儿童.研究组平均年龄、 性别分别为（7.6±1.3岁、 男性49例,女性51例）,对照组平均年龄、 性别分别为（7.2±1.3岁、 男性45例、 女性55例）,对比①两组自身抗体阳性率.②两组补体和免疫球蛋白检测异常率.结果：①两组自身抗体阳性率比较有差异（P〈0.05）.②两组补体和免疫球蛋白检测异常率比较有差异（P〈0.05）.结论：系统性红斑狼疮患儿自身抗体及免疫球蛋白和补体水平与正常儿童存在明显差异,通过实验室指标的测定可以帮助临床医生判断疾病的活动性,指导治疗.Objective： This study aims to investigate the levels ofautoantibodies, immunoglobulin and complement in children with systemic lupus erythematosus （SLE） . Methods： Children with systemic lupus erythematosus （SLE） and characterized by skin rash, fever and joint pain in our hospital from February 2014 to January 2016 were selected. The control group were healthy children for physical examination. Results： （1）There was signiffcant difference in the positive rate of autoantibodies between the two groups （P〈0.05） . （2） There was statistical difference in the abnormal rate of complement and immunoglobulin between the two groups （P〈0.05） . Conclusion： There were obvious differences in levels ofautoantibodies, immunoglobulin and complement in children with systemic lupus erythematosus （SLE） , comparing to the control group. These laboratory indicators can help the clinician judging the disease and guide treatment.

关 键 词：系统性红斑狼疮 自身抗体 免疫球蛋白 补体 

分 类 号：R446.62[医药卫生—诊断学]