速碧林对孕产妇围产期深静脉血栓发生率的影响  

Effect of nodroparin on perinatal incidence of deep venous thrombosis

作　　者：曲首辉[1] QU Shou-hui(Department of the Second Obstetrics, The First People＇s Hospital of Zhengzhou, Henan 450003, Chin)

机构地区：[1]郑州市第一人民医院产二科,河南450003

出　　处：《社区医学杂志》2017年第22期17-19,共3页Journal Of Community Medicine

摘　　要：目的分析孕产妇围产期应用速碧林对深静脉血栓发生率的影响。方法选取2016年4月—2017年4月接受分娩手术的产妇162例,按照随机分配原则均分为对照组和研究组,各81例。两组产后均给予常规抗血栓治疗,研究组在此基础上给予速碧林治疗。观察两组产妇分娩后新生儿体重和胎盘平均重量,产妇机体凝血功能状况以及用药后不良反应发生情况。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果研究组新生儿胎龄、体重、及胎盘重量[(38.04±3.87)w、(3.76±0.84)kg、(436.91±61.52)g]高于对照组[(36.86±3.73)w、(2.48±0.77)kg、(345.6±55.42)g](均P<0.05),研究组新生儿窒息发生率(1.23%)低于对照组(11.11%);研究组治疗后Fbg和D-二聚体含量[(4.1±1.9)mg/L、(2.3±0.8)g/L]与对照组[(5.2±4.1)mg/L、(1.9±0.8)g/L]比较,差异有统计学意义(均P<0.05);研究组治疗后不良反应发生率低于对照组(P<0.05)。结论速碧林应用在孕产妇围术期可有效降低深静脉血栓发生率,取得理想的抗血栓效果。Objective To study the effect of nodroparin on the incidence of deep venous thrombosis.Methods A total of 162 cases of delivery women from April 2016 to April 2017 were randomly divided into the control group and the study group,（81 cases in each group）.The two groups were given routine postpartum antithrombotic therapy,the study group was given nodroparin based on nodroparin treatment.Neonatal weight and average weight of placenta,maternal coagulation function and adverse drug reactions were observed in two groups after delivery.Measurement data uses t test,count data uses χ~2 test,P〈0.05 is considered statistically significant.Results Week-age,neonatal weight,and placental weight of neonatus in the study group [（38.04＋3.87） w,（3.76＋0.84） kg,（436.91＋61.52） g] were higher than that of the control group [（36.86＋3.73） w,（2.48＋0.77） kg,（345.6＋55.42） g]（all P〈0.05）.The neonatal asphyxia incidence of study group（1.23%） was significantly lower than the control group（11.11%）;the study group after the treatment of Fbg and D-two dimer content [（4.1＋1.9）,mg/L（2.3＋0.8） g/L] and control group [（5.2＋4.1）mg/L,（1.9＋0.8） g/L],there was significant differences（P〈0.05）.The adverse reaction after the occurrence of study group was significantly lower than the control group（P〈0.05）.Conclusion Nodroparin in pregnant women during the perioperative period can effectively reduce the incidence of deep venous thrombosis,get ideal antithrombotic effect.

关 键 词：速碧林 深静脉血栓 孕产妇 

分 类 号：R654.4[医药卫生—外科学]