精液异常患者人口学因素调查  

Investigation of demographic characteristics in patients with abnormal semen

作　　者：陈慧[1] 孟昱时[1] 刘仲伟[1] 陈静思[1] 苏娅[1] 宋家美 

机构地区：[1]昆明医科大学第二附属医院生殖医学科,云南650101

出　　处：《中国生育健康杂志》2017年第6期533-537,共5页Chinese Journal of Reproductive Health

基　　金：昆明医科大学"十三五"校级学科建设重点项目(J1301819)

摘　　要：目的研究中重度少弱精子症、梗阻性无精子症与患者年龄、不育时间、文化程度、职业、体重指数、民族的相关性。方法回顾性收集2005年1月至2015年12月在昆明医科大学第二附属医院生殖医学科接受体外受精-胚胎移植的5 411例临床资料,根据男方精液分析异常类型,发现中重度少弱精子症有534例,无精子症有174例,精液分析正常有4 703例,比较这三组人群在不同的年龄组、文化程度、职业及民族等方面的患病率,采用Logistic回归分析上述因素与精液异常发生的相关性。结果 (1)年龄<30岁组的无精子症患病率(5.5%)高于其他年龄组,差异有统计学意义;不育时间≥15年组的少弱精子症(15.6%)及无精子症(7.1%)患病率高于其他不育时间组,差异有统计学意义;文化程度为小学组的少弱精子症患病率(6.6%)低于初中组和大学及以上组,差异有统计学意义;高中组(3.1%)、大学及以上组(1.7%)的无精子症患病率均低于其他文化程度组,差异有统计学意义;职业为工农组的无精子症患病率(4.2%)明显高于其他职业组,差异有统计学意义;民族为纳西族的少弱精子症患病率(16.9%)高于汉族(9.4%),傣族的无精子症患病率(7.5%)高于汉族(2.9%),差异均有统计学意义。(2)随年龄增加,患无精子症可能性下降,即年龄是无精子症的保护因素(P<0.05,OR=0.78);随不育时间增加,患少弱精子症及无精子症的可能性增加,即不育时间是少弱精子症的危险因素[(P<0.05,OR=1.23),(P=0.03,OR=1.05)];随文化程度升高,患无精子症可能性下降,即文化程度是无精子症的保护因素(P<0.05,OR=0.62);纳西族相对于汉族是少弱精子症的危险因素(P=0.03,OR=1.98)。结论年龄是无精子症的保护因素,年龄越大,患无精子症的可能性越小,而青年人群中无精子症患病率最高;不育时间是少弱精子症及无精子症的危险因素,随不育时间延长,患少弱精子症及无精子症�Objective To study the correlation between demographic characteristics, and moderate or severe oligoasthenospermia and obstructive azoospermia. Methods Clinical data of 5 411 cases, who received IVF-ET or ICSI treatment in the Second Affiliated Hospital of Kunming Medical University of reproductive medicine, were retrospectively collected from January 2005 to December 2015. Three groups were divided based on the type of abnormal semen. 534 cases were in severe oligoasthenospermia group, 174 cases were in azoospermia group, 4 703 cases were in normal group. Demographic characteristics were compared between the three groups, which including age, duration of infertility, education, occupation, body mass index and nationality. Logistic regression model was used to analyze the correlation between the above factors and abnormal semen. Results （ 1 ） The prevalence of azoospermia in age younger than 30 years old was 5.5% which was statistically higher than other age groups; prevalence of oligoasthenospermia and azoospermia was 15.6% and 7. 1% among people with ≥ 15 years of duration of infertility, which were statistically higher than other groups. Prevalence of oligoasthenospermia among people with primary school was 6.6%, which was significantly lower than other group. Prevalence of azoospermia among people high school and University and above group was 3. 1% and 1.7% respectively which was significantly lower than other groups. Prevalence of azoospermia among workers and peasants was 4. 2% which was significantly higher than other occupation group. The prevalence of oligoasthenospermia in Naxi nationality was 16.9%, prevalence of azoospermia in Dai nationality was 7.5%, which was higher than that of Han nationality. （2） With age increasing, the possibility of azoospermia was decreasing, that is, age was a protective factor for azoospermia （P 〈 0. 05, OR = 0.78）. The possibility of oligoasthenospermia and azoospermia was increased with duration of infertility prolonging, that is , it was a risk factor f

关 键 词：体外受精 卵细胞质内单精子注射 少弱畸精子症 梗阻性无精子症 

分 类 号：R698.2[医药卫生—泌尿科学]