白矾星点设计-效应面法炮制工艺研究  

Study on Processing Technology of Alum by Central Composite Design and Response Surface Method

作　　者：李伟[1] 李瑞海[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中国药师》2017年第12期2135-2138,共4页China Pharmacist

基　　金：中国药典委员会项目(编号:2015-YP-01)

摘　　要：目的:利用烤箱炮制结合星点设计-效应面法优选白矾的最佳炮制工艺,为炮制白矾规范化生产提供依据。方法:以白矾为原料,在单因素试验基础上,选取炮制温度、炮制时间、白矾质量3个因素为自变量,用滴定法对枯矾中硫酸铝钾进行含量测定,采用星点设计-效应面法优选白矾最佳炮制工艺。结果:白矾的最佳炮制工艺为:炮制温度:250℃;炮制时间:40 min;白矾质量:8 g。结论:星点设计-效应面法选白矾炮制工艺,方法简便,工艺稳定且预测性良好,可为炮制白矾规范化生产提供依据。Objective： To optimize the processing technology of alum by using oven processing combined with central composite design and response surface method to provide basis for processing standardization production of alum. Methods： Alum as the raw ma- terial and on the basis of single factor experiment, the processing temperature, processing time and alum amount were used as the three independent variables factors. A titration method was applied in the content determination of aluminium potassium sulfate in withered alum, and a central composite design and response surface method was used to optimize the processing technology of alum. Results： The optimal processing technology of alum was as follows： the processing temperature was 250℃ with 40-minnte processing time and 8 g alum. Conclusion： The optimized alum processing technology by central composite design and response surface method is simple, stable and predictable, which can provide basis for the processing standardization production of alum.

关 键 词：白矾 星点设计-效应面法 烤箱 炮制工艺 

分 类 号：R283.3[医药卫生—中药学]