1145例河北地区汉族人群HPA-3,15系统基因频率分析  

Gene frequencies of HPA-3, 15 in 1 145 Hebei Han population

作　　者：王振雷[1] 李茵[1] 苏蔓[1] 胡光磊[1] 张虹[1] 赵佳[1] 戚海[1] 张蓓[1] 李醒[1] 何路军[1] 

机构地区：[1]河北省血液中心,石家庄050071

出　　处：《北京医学》2017年第11期1164-1166,共3页Beijing Medical Journal

摘　　要：目的总结河北地区汉族人群HPA-3,15系统基因频率。方法采用PCR-SSP方法对1 145例河北地区汉族人群血小板捐献者进行HPA-3、15系统基因分型并统计结果。结果 1 145例河北地区汉族血小板捐献者中,HPA-3a,3b,15a,15b的基因频率分别为56.38%,43.62%,53.06%和46.94%。在随机输血中,HPA-3,15抗原的不配合率分别为37.08%和37.41%。结论河北地区汉族人群HPA-3,15抗原的不配合率较高,推测可能为河北地区血小板输血中造成输注不合的主要原因。Objective To investigate the gene frequencies of HPA-3, 15 systems in Hebei Han population. Meth- ods A total of 1 145 blood samples from Hebei Han platelet donors was genotyped using PCR-SSP method, and then the data were analyzed statistically. Results In 1 145 Hebei Han platelet donors, the gene frequency ofHPA-3a, 3b, 15a, 15b was 56.38%, 43.62%, 53.06% and 46.94%, respectively. In random blood transfusion, the mismatch rate of HPA-3, 15 an- tigens were 37.08% and 37.41%, respectively. Conclusion The HPA-3,15 antigens mismatch rate of Hebei Hart popula- tion is higher than other HPA antigens, suggesting that the HPA-3,15 antigens are the main reason for transfusion reaction during platelet transfusion in Hebei Province.

关 键 词：人类血小板同种抗原 分型 基因频率 

分 类 号：R440[医药卫生—诊断学]