呼出气一氧化氮水平与结缔组织病相关肺间质病变的相关性分析  

Correlative analysis of fractional exhaled nitric oxide level and connective tissue disease-related pulmonary interstitial lesions

作　　者：梁志强[1] 庞桂芬[2] 张勃[2] 张庆[2] 姜凤云[1] 赵蕾[1] 王雪燕[1] 杜丽艳[2] 郝长来[1] 

机构地区：[1]承德医学院附属医院风湿免疫科,067000 [2]承德医学院附属医院呼吸内科,067000

出　　处：《中华保健医学杂志》2017年第6期474-476,共3页Chinese Journal of Health Care and Medicine

基　　金：承德市科学技术研究与发展计划项目(201701A052)

摘　　要：目的探究呼出气一氧化氮(FeNO)水平与结缔组织病相关肺间质病变(CTD-ILD)的相关性。方法选取2015年1月~2016年12月承德医学院附属医院收治的34例CTD-ILD患者,设为CTD-ILD组;另选取42例单纯肺间质病变(ILD)患者,设为ILD组;选取同期健康体检者40例,设为对照组。对比3组受检者的肺功能及FeNO水平差异,并对FeNO水平与血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗核抗体(ANA)、第1秒用力呼气量占肺活量比值(FEV1/FVC)的相关性进行统计分析。结果 CTD-ILD组与ILD组的最大呼气流量占比(PEF)、1秒用力呼气末容积占比(FEV1)、用力肺活量占比(FVC)相比,差异均无统计学意义(P>0.05),但CTD-ILD组和ILD组的肺功能指标PEF、FEV1、FVC、FeNO与对照组相比差异均有统计学意义(P<0.05);3组FeNO水平对比显示,CTD-ILD组>ILD组>对照组,各组间差异均有统计学意义(P<0.05)。FeNO水平与CRP呈显著正性相关(P<0.05)。结论 CTD-ILD患者的FeNO水平有明显增高趋势,与机体的炎症反应及肺功能显著相关,FeNO测定结合肺功能检查对于CTD-ILD诊断,提供了新的思路。Objective To investigate the correlation between exhaled nitric oxide （FeNO）and connective tissue disease- related pulmonary interstitial lesions （CTD-ILD）. Methods Thirty-four patients with CTD-ILD were enrolled in this study. The 34 patients were treated for CTD-ILD and 42 patients for pulmonary interstitial disease（ILD）. The ILD group and healthy （control）group were measured for rheumatoid factor（RF）,antinuclear antibody（ANA）and C-reactive protein（CRP）,and the changes of lung function and FeNO level were compared with those of the three groups. One-second rate （FEV1/FVC）correlation analysis was performed. Results There was no significant difference between the CTD-ILD group and the ILl） group （PEF）, l-second forced expiratory volume （FEV1）or forced vital capacity （FVC）（P 〈 0.05）. Compared with the control group,the pulmonary function indexes of the CTD-ILD group and the ILD group were significantly different from those of the control group （P 〈 0.05）. The comparison of FeNO levels showed that CTD-ILD group 〉 ILD group 〉 control group （P 〈 0.05）. The level of FeNO positively correlated with CRP levels （P 〈 0.05）. Conclusion The level of FeNO in CTD-ILD patients is significantly higher than that in patients with CTD-ILD,which is related to the inflammatory response and pulmonary function of CTD-ILD. As such,the FeNO levels can be used as a diagnostic index of CTD-ILD.

关 键 词：结缔组织病 肺间质病变 呼出气一氧化氮 肺功能 

分 类 号：R563[医药卫生—呼吸系统]