药物转运体表观遗传调控机制的研究进展  

Research progress on regulation mechanism of epigenetic modifications for drug transporters

作　　者：杨世磊 刘克辛[1] 

机构地区：[1]大连医科大学药学院临床药理教研室,辽宁大连116044 [2]大连医科大学附属第一医院药学部,辽宁大连116011

出　　处：《药物评价研究》2017年第9期1229-1234,共6页Drug Evaluation Research

摘　　要：药物转运体在体内药物吸收、分布和排泄过程中发挥着重要的作用。转运体在各组织器官的分布和表达受到表观遗传修饰调控,导致某些药物体内处置过程出现明显的个体差异。随着表观遗传学的发展,基于表观遗传修饰(如DNA甲基化、组蛋白修饰、microRNA干预等)调控药物转运体的相关研究越来越多。对表观遗传调控药物转运体研究进行综述。Drug transporters play a key role in drug absorption, distribution and excretion. The distribution and expression of transporters in tissues and organs are regulated by epigenetic modifications, resulting in individual differences of drugs disposition significantly. With the development of epigenetics, researches on the regulation of drug transporters expression based on epigenetic modifications （DNA methylation, histone modification, microRNA interference, etc.） have been more and more reported. In this paper, we will summarize the epigenetic modifications regulating drug transporters.

关 键 词：药物转运体 表观遗传修饰 DNA甲基化 组蛋白修饰 MICRORNA 

分 类 号：R962.2[医药卫生—药理学]