中药多糖体外抗胃肠肿瘤作用的研究进展  

Research progress on polysaccharide of Chinese materia medica against gastrointestinal tumors in vitro experiments

作　　者：许峰巍 孟静岩[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《药物评价研究》2017年第11期1659-1663,共5页Drug Evaluation Research

基　　金：国家自然科学基金项目(81273636);天津市重大科技攻关项目(12ZCDZSY16800)

摘　　要：肿瘤是严重危害人体健康的疾病之一,胃肠肿瘤是我国人口中消化系肿瘤的多发病种,而针对其进行放疗、化疗治疗的同时对正常细胞毒性不容忽视。中药多糖抗肿瘤的同时,能提高人体免疫功能,且对正常细胞无伤害,使其成为抗肿瘤研究的热点。对中药多糖体外抑制人胃癌细胞系MGC-803、SGC-7901,人结直肠腺癌细胞Lo Vo、HCT-116、HT-29的增殖和促凋亡作用及相关作用机制进行综述,旨在为中药多糖的抗胃肠肿瘤的临床研究提供依据。Tumor is a seriously disease that endanger human health. Gastrointestinal cancer is one of the most prevalent types of digestive system cancers among the Chinese population. While radiotherapy and chemotherapy kill cancer cells, their toxicity to normal cells cannot be ignored. Hence, polysaccharides from Chinese materia medica（CMM） have been the focus of anti-tumor research, as they can improve functions of the immune system and do not harm to normal cells. In this review, we have analyzed the recent advances in the study of the effects of polysaccharides from CMM on human gastric cancer cell lines（MGC-803 and SGC-7901） and intestinal tumor cell lines（Lo Vo, HCT-116, and HT-29） in vitro. The purpose of this study is to provide a material basis for clinical research of polysaccharides from CMM.

关 键 词：中药多糖 天然化合物 抗肿瘤 胃肿瘤细胞株 肠肿瘤细胞株 

分 类 号：R285.5[医药卫生—中药学]