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作 者:邵远洋 徐国杰[1,2] 晋小雁 刘思琦 张弛 王娟[1] 马双双[1] 张彩娟[1] 邱敏懿 刘春生 王学勇[1]
机构地区:[1]北京中医药大学中药学院,北京100102 [2]北京中医药大学生命科学学院 [3]天津市河西区挂甲寺社区卫生服务中心
出 处:《北京中医药大学学报》2017年第11期946-953,共8页Journal of Beijing University of Traditional Chinese Medicine
基 金:国家自然科学基金项目(No.81274011);中央本级重大增减支项目(No.2060302);北京市自然科学基金项目(No.7152094)~~
摘 要:目的分析不同产地新鲜丹参中主要活性成分含量,合理评价鲜丹参药材品质。方法采用LTQ-Orbitrap XL高分辨质谱仪测定全国7个不同产地新鲜丹参中5个丹酚酸类和12个丹参酮类成分。在此基础上,进行主成分分析(PCA)和最小二乘法分析(PLS)。结果同一产地新鲜丹参主要活性成分的含量基本一致,不同产地新鲜丹参主要活性成分的含量差异显著;其中,湖北产区丹参的丹酚酸类成分含量最高,四川和河南产区丹参的丹参酮I和丹参酮IIA成分含量最高;PCA和PLS分析显示,大部分活性成分的含量分布具有明显的产地特异性。结论不同产地新鲜丹参质量差异显著并具有较显著的产地特异性,以新鲜丹参药材作为品质评价材料,是现今基于干药材为品质评价原料研究方法的有益补充,为更全面综合的评价丹参及其他中药材探索了新的研究途径。Objective To analyze the content of active components in fresh Danshen (Radix Salviae Miltiorrhizae, Red Sage Root) from different producing areas, and review reasonably the medicinal quality of fresh Danshen. Methods The content of 5 salvianolic acids and 12 tanshinones in fresh Danshen, from 7 different producing areas, were determined by applying LTQ-Orbitrap XL high-resolution mass spectrometer. On this basis, all content were analyzed by using principal component analysis (PCA) and partial least square (PLS) analysis. Results The content of active components in fresh Danshen from the same producing area were basically the same, and difference was significant in content of active cornponents among fresh Danshen from different producing areas. The content of salvianolic acids was the highest in fresh Danshen from Hubei, and content of tanshinone I and tanshinone IIA were the highest in fresh Danshen from Sichuan and I-Ienan. The analysis results of PCA and PLS showed that the distribution of most active components had a distinct regional specificity. Conclusion The difference is significant in quality of fresh Danshen from different producing areas, and they have a distinct regional specificity. Using fresh Danshen as quality evaluation materials, that is a useful supplement to review quality of raw medicinal materials based on dry herbs. It explored a new and more comprehensive approach for reviewing other Chinese medicinal materials.
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