山东省2008-2015年首次接受艾滋病免费抗病毒治疗的HIV/AIDS流行病学特征分析  

Analysis of epidemiology characteristics among HIV/AIDS who joined the antiviral treatment in Shandong Province from 2008 to 2015

作　　者：朱晓艳[1] 杨兴光[1] 廖玫珍[1] 黄鹏翔[1] 郝连正[1] 林彬[1] 李金海[1] 王国永[1] 钱跃升[1] 陶小润[1] 康殿民[1] 黄涛[1] 

机构地区：[1]山东省疾病预防控制中心艾滋病防制所,山东济南250014

出　　处：《中华疾病控制杂志》2017年第12期1195-1199,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家科技重大专项(2014ZX10001002-001-003)

摘　　要：目的了解山东省2008-2015年艾滋病病毒(human immunodeficiency virus,HIV)感染者/艾滋病(acquired immune deficiency syndrome,AIDS)病人开始艾滋病抗病毒治疗时流行病学特征。方法收集山东省2008-2015年启动艾滋病抗病毒治疗的患者入选时的基本信息,应用Excel 2010建立数据库,应用SPSS 23.0软件进行数据分析。结果 5 330例研究对象中男性占86.1%,已婚或同居者居多,占42.8%,平均年龄为(34.8±10.6)岁。从2008-2015年,接受抗病毒治疗的HIV/AIDS患者中男性、未婚及35岁以下的构成比呈上升趋势。性传播占93.6%,2008-2015年开始抗病毒治疗的HIV/AIDS患者中同性性传播比例升高。治疗开始时80.7%为世界卫生组织临床分期Ⅰ期,开始治疗时CD4^+T淋巴细胞M(P_(25),P_(75))为272.4(139.0,370.0)个/μl,86.1%开始治疗时无任何症状与体征,HIV确诊阳性时间与开始治疗时间间隔中位数为3个月。从2008-2015年,治疗开始时为临床分期Ⅰ期、CD4^+T淋巴细胞≥200个/μl、无任何症状的HIV/AIDS构成比呈上升趋势。结论山东省艾滋病抗病毒治疗时机的选择有所提前,应进一步采取措施早发现、早治疗。Objective To understand the epidemiological characteristics of HIV/AIDS who joined the highly ac- tive antiretroviral therapy in Shandong Province from 2008 to 2015. Methods The basic information of HIV/AIDS who joined the antiviral treatment in Shandong Province from 2008 to 2015 were collected, and the database was established by Excel 2010. Data were analyzed using SPSS 23. 0. Results Of the 5 330 cases, 86. 1% were male and 42. 8% were mar- ried ,the average age was 34. 8 ＋ 10. 6 years old. The proportion of the HIV/AIDS patients that were being male, unmar- ried, under 35 years older showed a trend of increase. 93.6% of them were infected through sexual contacts, and the ho- mosexual transmission increased during 2008 -2015. 80. 7% were in clinical phase I. The average baseline CD4 ~T lym- phocyte count was 272.4 （ 139. 0,370. 0）. 86. 1% of them were without any symptoms when joined treatment. Median of the interval between HIV confirmation and HAART initiation was 3 months. Proportion of the HIV/AIDS patients that were WHO I , with higher baseline CD4 ＋T lymphocyte count, without any symptoms showed a trend of increase from 2008 to 2015. Conclusions In Shandong province, the timing of HIV/AIDS receiving antiretroviral therapy was earlier than be- fore, the detection and treatment on HIV should be earlier.

关 键 词：获得性免疫缺陷综合征 抗逆转录病毒治疗 高效 流行病学研究 

分 类 号：R512.91[医药卫生—内科学] R181[医药卫生—临床医学]