安徽省阜阳市HIV/HCV共感染者抗病毒治疗服药依从性及影响因素分析  

Study on influencial factors of adherence to anti-retroviral treatment among people who co-infected with HIV/HCV in Fuyang City,Anhui Province

作　　者：范引光[1] 朱志伟 马炜祥 丁志强 程国金 戴色莺[3] 叶冬青[1] 

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,安徽合肥230032 [2]阜阳市京九区卫生站,安徽阜阳236000 [3]安徽省疾病预防控制中心艾滋病防治科,安徽合肥230000

出　　处：《中华疾病控制杂志》2017年第12期1204-1208,共5页Chinese Journal of Disease Control & Prevention

基　　金：安徽省自然科学基金(1608085MH174);省级质量工程研究项目(2016jxxm0522);国家级大学生创新创业项目(201710366028)

摘　　要：目的探讨安徽省人类免疫缺陷病毒(human immunodeficiency virus,HIV)/丙型肝炎病毒(hepatitis C virus,HCV)共感染者抗病毒治疗服药依从性现状及其影响因素,为制定综合管理策略提供理论依据。方法采用横断面研究方法,对安徽省阜阳市接受抗病毒治疗1年以上的HIV/HCV共感染者进行问卷调查,收集患者的一般信息和服药情况,采用多因素Logistic回归分析对其服药依从性的影响因素进行分析。结果 256例HIV/HCV共感染者在过去1个月内抗病毒治疗的服药不依从率为34.0%,结婚年限较长(OR=3.049,95%CI:1.435~6.481,P=0.004)、抗病毒治疗时间较长(OR=1.803,95%CI:1.251~2.599,P=0.002)和饮酒者(OR=2.512,95%CI:1.152~5.478,P=0.021)抗病毒治疗依从性较差,而女性(OR=0.180,95%CI:0.089~0.366,P<0.001)和设置服药提醒者(OR=0.315,95%CI:0.159~0.626,P=0.001)的抗病毒治疗依从性较好。结论降低社会公众的艾滋病歧视和提高HIV/HCV共感染者抗病毒治疗的信心,是改善抗病毒治疗服药依从性的关键。Objective To investigate the adherence to anti-retroviral treatment and related factors among human immunodeficiency virus （HIV） and hepatitis C virus （HCV） co-infectors. Methods In this cross-sectional study, 256 HIV and HCV co-infectors were recruited by convenience sampling method, and information about demography, taking medicine and therapy were collected and analyzed. Results A total of 256 HIV/HCV co-infectors were investigated, 34. 0% of them missed dose in the last month. Multiple Logistic regression analysis showed that HIV/HCV co-infectors with long marriage （ OR = 3. 049, 95% CI： 1. 435-6. 481, P = 0. 004） , longer time of treatment with antiretroviral therapy （ART） i OR = 1. 803, 95% CI： l. 251-2. 599, P = 0. 002） , frequent alcohol consumption （ OR = 2. 512, 95% CI： 1. 152：5.478, P=0. 021 ） were risk factors of missed dose, while female （OR =0. 180, 95% CI： O. 089-0. 366, P 〈 0. 001） and co-infectors who take a reminder method （OR =0. 315, 95% C1： 0. 159-0. 626, P =0. 001 ） were protective factors for missed dose. Conclusions The ART adherence rate of HIV/HCV co-infectors was lower in Anhui Province, comprehensive intervention measures should be taken to promote the ART adherence.

关 键 词：HIV 获得性免疫缺陷综合征 肝炎病毒 抗病毒药 

分 类 号：R181[医药卫生—流行病学]