Production, purification, characterization, immobilization, and application of Serrapeptase： a review  

作　　者：Selvarajan Ethiraj Shreya Gopinath 

机构地区：[1]Department of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu, India

出　　处：《Frontiers in Biology》2017年第5期333-348,共16页生物学前沿（英文版）

摘　　要：BACKGROUND： Serrapeptase is a proteolytic enzyme with many favorable biological properties like anti-inflammatory, analgesic, anti-bacterial, fibrinolytic properties and hence, is widely used in clinical practice for the treatment of many diseases. Although Serrapeptase is widely used, there are very few published papers and the information available about the enzyme is very meagre. Hence this review article compiles all the information about this important enzyme Serrapeptase. METHODS： A literature search against various databases and search engines like PubMed, SpringerLink, Scopus etc. was performed. RESULTS： We gathered and highlight all the published information regarding the molecular aspects, properties, sources, production, purification, detection, optimizing yield, immobilization, clinical studies, pharmacology, interaction studies, formulation, dosage and safety of the enzyme Serrapeptase. CONCLUSION： Serrapeptase is used in many clinical studies against various diseases for its anti-inflammatory, fibrinolytic and analgesic effects. There is insufficient data regarding the safety of the enzyme as a health supplement. Data about the anti- atherosclerotic activity, safety, tolerability, efficacy and mechanism of action of the Serrapeptase are still required.BACKGROUND： Serrapeptase is a proteolytic enzyme with many favorable biological properties like anti-inflammatory, analgesic, anti-bacterial, fibrinolytic properties and hence, is widely used in clinical practice for the treatment of many diseases. Although Serrapeptase is widely used, there are very few published papers and the information available about the enzyme is very meagre. Hence this review article compiles all the information about this important enzyme Serrapeptase. METHODS： A literature search against various databases and search engines like PubMed, SpringerLink, Scopus etc. was performed. RESULTS： We gathered and highlight all the published information regarding the molecular aspects, properties, sources, production, purification, detection, optimizing yield, immobilization, clinical studies, pharmacology, interaction studies, formulation, dosage and safety of the enzyme Serrapeptase. CONCLUSION： Serrapeptase is used in many clinical studies against various diseases for its anti-inflammatory, fibrinolytic and analgesic effects. There is insufficient data regarding the safety of the enzyme as a health supplement. Data about the anti- atherosclerotic activity, safety, tolerability, efficacy and mechanism of action of the Serrapeptase are still required.

关 键 词：Serrapeptase proteolytic enzyme ANTI-INFLAMMATORY FIBRINOLYTIC 

分 类 号：Q0[生物学]