18F-FDG代谢分布特点对高代谢肺占位病变的鉴别诊断价值  

Value of ^(18)F-FDG Distribution for Differential Diagnosis of High Metabolic Lung Lesions

作　　者：周妮娜[1] 李囡[1] 于江媛[1] 王雪鹃[1] 朱华[1] 范洋 杨志[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《肿瘤防治研究》2017年第12期823-826,共4页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81371592,81401467,81571705,81501519)

摘　　要：目的探讨^(18)F-FDG代谢分布特点对肺部高代谢占位病变的鉴别诊断价值。方法选择因肺占位行^(18)F-FDG PET/CT检查的病例,病变FDG代谢活跃且不均匀、有穿刺或手术病理者共102例,分为肺癌组71例、炎性病变组31例。测量并计算病灶近心端/远心端的SUV_(max)比值(P/D值),将比值分为两种类型,即P/D>1或P/D<1,采用卡方检验比较两组间比值分型的差异。结果肺癌组以P/D>1为主,占91.5%(65/71),炎性病变组以P/D<1为主,占80.6%(25/31),两组差异有统计学意义(P<0.001)。结论肺癌^(18)F-FDG代谢分布多为近心端高于远心端,炎性病变代谢分布多为远心端高于近心端。^(18)F-FDG代谢分布特点可以为肺部高代谢占位的鉴别提供参考,提高诊断准确率。Objective To investigate the value of 18F-FDG distribution in differentiation diagnosis of high metabolic lung lesions. Methods We included 102 patients who had lung lesions and underwent PET/CT in this study. The lesions had high and inhomogeneous FDG uptake. All the lesions had pathology results with puncture or surgery. Lung cancer group included 71 cases, inflammatory lesions group included 31 cases. The SUVmax ratio of the proximal/distal part of the lesion （P/D value） was measured and calculated. The ratios were divided into two types, P/D〉1 or P/D〈1. The difference between the two groups was compared by Chi- square test. Results Lung cancer group was mainly with P/D〉 1, accounting for 91.5% （65/71）, inflammatory lesions group was mainly with P/D〈1, accounting for 80.6% （25/31）, the difference between the two groups is statistically significant （P〈0.001）. Conclusion The FDG activation distribution in lung cancer is higher in proximal part, while that in inflammatory lesion is higher in distal part. The FDG activation distribution is valuable for high metabolic lung lesions, to reduce the false positive diagnosis of 18F-FDG PET/CT.

关 键 词：肺癌 肺炎性病变 18F-FDG PET/CT 鉴别诊断 代谢分布 

分 类 号：R734.2[医药卫生—肿瘤]