关于新生儿期几种药物是否作过敏试验的探讨  

Clinical observation of several drugs on choice of allergic experiment before injection in newborns

作　　者：李建敏[1] 程平[1] 刘学胜 于志英[1] 程传勋[1] 

机构地区：[1]河南新乡市中心医院,453000 [2]河南原阳县医院

出　　处：《中国基层医药》2002年第8期692-693,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨几种容易发生过敏反应的药物在新生儿时期应用时是否可以不作过敏试验。方法　于 1978年 6月至 2 0 0 1年 6月对我院新生儿病房住院的 5 84 3例新生儿 ,应用青霉素、细胞色素C、普鲁卡因、破伤风抗毒素几种药物时不作过敏试验直接用药 ,用药后严密观察病情变化。结果　经 2 3年对 5 84 3例新生儿不作过敏试验 ,直接应用上述几种药物 ,通过临床严密观察 ,没有 1例发生过敏反应。结论　新生儿是一特殊群体 ,此时期机体免疫功能暂时缺陷 ,免疫生理及免疫病理与成人有一定差别 ,新生儿期不易发生典型的速发型变态反应。经 2 3年临床用药观察未发现一例新生儿出现过敏反应。Objective To explore the application of several allergic drugs without allergic experiment before injection in newborns.Methods 5843 cases of newborns were injected with penicillin,cytochrome C,procaine,tetanus antitoxin without allergic experiment from June 1978 to June 2001.Clinical response was observed strictly after injection.Results No drug allergy was found in 5843 cases during 23 years of clinical observation.Conclusion The newborn is a special group.Their immune function is defective temporarily.Their immune physiology and pathology are different from those of adults.Newborns do not easily occur acute type allergy.

关 键 词：新生儿 免疫特点 过敏试验 合理用药 

分 类 号：R722.1[医药卫生—儿科]