禽源呼肠孤病毒诱导宿主免疫应答研究进展  

The Research Advance of Host Immune Response Induced by Avian-origin Reovirus

作　　者：池晓娟[1] 邵文涵 陈吉龙[1] 陈月香 王松[1] 

机构地区：[1]福建农林大学动物科学学院,闽台动物病原生物学福建省高校重点实验室,福州350002 [2]福建省福州市动物疫病预防控制中心,福州350009

出　　处：《畜牧兽医学报》2017年第12期2249-2257,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31402217;U1305212);福建省教育厅资助省属高校专项课题(JK2015011)

摘　　要：禽源呼肠孤病毒是一类重要的禽类病原体,能引起感染家禽和水禽法氏囊、脾和胸腺等器官严重受损,造成免疫抑制,且易与其他病原体混合感染,极大地阻碍了全球养禽业的健康发展。天然免疫应答具有反应迅速、不针对特定抗原且作用范围广的特性,是当前免疫学和微生物学的研究热点。适应性免疫应答能够排除体内特异性抗原异物,抵抗相同病原体的再次入侵,是预防接种的免疫学基础。本文将从禽源呼肠孤病毒诱导宿主天然免疫应答和适应性免疫应答两方面,阐述此类病毒感染对宿主免疫系统的影响,以期为靶向病毒和宿主免疫反应的疫苗设计提供参考依据。Avian-origin reovirus, which is a kind of important poultry and waterfowl pathogen, can cause serious damage to the bursa of Fabricius, spleen and thymus of infected birds, resulting in immunosuppression and increased susceptibility to secondary diseases that greatly hinder the healthy development of global poultry and waterfowl industry. The innate immune response is the hotspot in the field of microbiology and immunology due to its earlier and quick non-specific response against pathogens. Adaptive immune response can eliminate the intruding pathogens, and defend against reinfection of the same pathogens, which provides immunological basis for the immunization of host. In this review, we highlight the current understanding of host innate immune response and adaptive immune response induced by avian-origin reovirus and the effects of such virus infection on the host immune system. This review will provide a basis for understanding the virus-host interaction and vaccine development.

关 键 词：禽源呼肠孤病毒 天然免疫应答 适应性免疫应答 免疫抑制 

分 类 号：S858.35[农业科学—临床兽医学] S852.659.4[农业科学—兽医学]