拉氧头孢钠注射剂联合甲硝唑片治疗肠无神经节细胞症患儿的临床研究  

Clinical trial of latamoxef sodium injection combined with metronidazole tablets in the treatment of children with intestinal ganglion cell disease

作　　者：马宏图[1] 李晓庆[1] 王佚[1] 刘伟[1] 郭振华[1] 

机构地区：[1]重庆医科大学附属儿童医院胃肠新生儿外科儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014

出　　处：《中国临床药理学杂志》2017年第23期2368-2370,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81200258)

摘　　要：目的观察拉氧头孢钠注射剂联合甲硝唑片治疗肠无神经节细胞症的临床疗效及安全性。方法将90例肠无神经节细胞症患儿随机分为对照组和试验组,每组45例。所有患儿均在腹腔镜辅助下实施经肛门巨结肠根治术治疗。术后,对照组每次给予甲硝唑0.4 g,tid,口服;试验组在对照组治疗的基础上,给予拉氧头孢钠2.0 g,静脉滴注,qd。2组患儿均治疗21 d。比较2组患儿的临床疗效和药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为93.33%(42例/45例)和80.00%(36例/45例),差异有统计学意义(P<0.05)。试验组的药物不良反应主要有小肠结肠炎、便秘、尿潴留,药物不良反应发生率为8.89%(4例/45例);对照组的药物不良反应主要有小肠结肠炎、直肠肌鞘夹层感染、便秘、尿潴留,药物不良反应发生率为31.11%(14例/45例),差异有统计学意义(P<0.05)。结论拉氧头孢钠注射剂联合甲硝唑片可以提高肠无神经节细胞症患儿的治疗效果,降低药物不良反应的发生率。Objective To observe the clinical efficacy and safety of latamoxef sodium injection combined with metronidazole tablets in the treatment of intestinal ganglion cell disease. Methods A total of 90 patients with intestinal ganglion cells were randomly divided into control group and treatment group,with 45 cases per group. All patients were treated with laparoscopic assisted radical resection of the large intestine.After operation, control group was given metronidazole 0. 4 g, tid,orally. The treatment group was given latamoxef sodium injection 2. 0 g,qd,intravenous injection,on the basis of control group. Two groups were treated for 21 d. The clinical efficacy and adverse drug reactions in two groups were compared. Results After treatment,the total effective rates in treatment group and control group were 93. 33%（ 42 cases/45 cases）and 80. 00%（ 36 cases/45 cases）, with significant difference（ P〈0. 05）. The main adverse drug reactions in treatment group were enterocolitis,constipation and urinary retention,with the incidence of8. 89%（ 4 cases/45 cases）. The adverse drug reactions in control group were small bowel disease,rectal muscle sheath infection,constipation and urinary retention, with the incidence of 31. 11%（ 14 cases/45 cases）. The difference was statistically significant between the two groups（ P〈0. 05）. Conclusion The combination of cefotaxime sodium and metronidazole could improve the therapeutic effect and reduce the incidence of adverse drug reactions.

关 键 词：拉氧头孢钠注射剂 甲硝唑片 肠无神经节细胞症 安全性 

分 类 号：R97[医药卫生—药品]