Castleman病的临床研究  

Clinical analysis of Castleman's disease

作　　者：袁海龙[1] 古力巴旦木.艾则孜 曲建华[1] 曹海洲[1] 段显琳[1] 徐建丽[1] 陈刚[1] 

机构地区：[1]新疆医科大学第一附属医院血液病中心,乌鲁木齐830054

出　　处：《中国临床药理学杂志》2017年第23期2446-2448,共3页The Chinese Journal of Clinical Pharmacology

基　　金：新疆维吾尔自治区自然科学基金资助项目(2013211A100)

摘　　要：目的探讨Castleman病的临床表现、病理特点、治疗方法以及转归等。方法回顾性分析自2011年3月至2014年5月在我院诊治的10例Castleman病患者的临床表现、实验室检查、病理及治疗等资料。结果 10例患者中,男性4例,女性6例;中位年龄44岁(30~71岁);单中心型(UCD)1例,广泛型(MCD)9例;浆细胞型3例(30%),透明血管型7例(70%),无混合型,其中1例UCD患者为透明血管型。1例UCD患者手术后治愈,1例患者MCD未接受化疗,8例患者化疗患者,其中1例完全缓解,6例病情稳定,1例疾病进展。无患者转变为淋巴瘤。随访中位时间为26.5月(13~64月),死亡患者1例,3年预期总体生存率为84.3%。结论 CD临床表现多样,诊断主要依靠病理。UCD治疗效果较好,MCD化疗及单克隆抗体治疗效果欠佳,缓解率低。Objective To investigate the clinical manifestations,pathological characteristics, treatment and outcome of Castleman ＇s disease（ CD）. Methods Retrospective analysis of clinical manifestations,laboratory examination,pathology and treatment of 10 patients with CD from March 2011 to May 2014 in our hospital was performed. Results 4 cases were males,6 cases were females,with a median age of 44 years（ 30-71 years old）. 1 case was unicentric Castleman ＇s disease（ UCD）,9 cases were multicentric Castleman ＇s disease（ MCD）.3 cases were hyaline-vascular type and 7 cases in plasma cell type according to pathological classification,non mixed type. 1 UCD case with HV type acquired remission after surgery. One case of MCD did not receive chemotherapy, eight cases were received chemotherapy,including one case of complete remission,6 cases of stable disease,one case of disease progression. None of the patients were transferred into lymphoma. The median follow-up time was 26. 5 months（ from 13 to 64 months）,1 patient died,3-year probabilities overall survival was84. 3%. Conclusion CD had various symptoms and signs. It was diagnosed by pathology. The UCD was often asymptomatic and curable by surgical excision of the mass,while MCD had a less favorable prognosis by chemotherapy and chemotherapy combined with monoclonal antibodies.

关 键 词：CASTLEMAN病 人类8型疱疹病毒 治疗 预后 

分 类 号：R97[医药卫生—药品]