三七总皂苷胃漂浮缓释片在家兔体内的释药研究  

In vivo Release Research of Panax Notoginseng Saponins Floating Sustained-Release Tablets in Rabbits

作　　者：邵亮 孙璐 冯敏 林宁 SHAO Liang;SUN Lu;FENG Min;LIN Ning(College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065;Pharmacy Department, Wuhan No.6 Hospital, Wuhan 430015)

机构地区：[1]湖北中医药大学药学院,湖北武汉430065 [2]武汉市第六医院药剂科,湖北武汉430015

出　　处：《湖北中医药大学学报》2017年第6期46-49,共4页Journal of Hubei University of Chinese Medicine

基　　金：湖北省教育厅科学技术研究项目(项目编号:D20101801)

摘　　要：目的测定PNS胃漂浮缓释片的体内药动学参数,并考察制剂体外释放与体内吸收的相关性。方法以人参皂苷Rg1为指标性成分,采用HPLC法测定PNS血药浓度,进行家兔体内的释药研究并拟合药动学参数。结果相对于普通片剂,PNS胃漂浮缓释片的达峰时间(t_(max))明显延长,达峰浓度(C_(max))明显降低,平均滞留时间(MRT)延迟约3h,AUC明显提高;体内外相关性回归方程为:Y=1.2208X+6.3239(r=0.9023)。结论 PNS胃漂浮缓释片体内释药过程平稳,缓释效果较好,并能有效提高制剂的生物利用度,且体内外释药过程具有一定的相关性。Objective To determine the ＆ vivo pharmacokinetic parameters of PNS floating sustained- release tablets, and investigate the linear relationship between the in vivo release and the in vivo absorption in rabbits. Methods Ginsenoside Rgl was chosen as the index component, plasma concentrations of PNS were determined by HPLC method, to study the drug release in vivo and estimate pharmacokinetic parameters. Results Compared with common tablets, the tmax of PNS gastric floating sustained-release tablets was significantly prolonged, the Cmax was significantly decreased, MRT was delayed by about 3h, AUC was significantly increased. The regression equation about the in vivo release and the in vivo absorption was Y = 1.2208 X ＋ 6.3239（r= 0.9023 ）. Conclusion In vivo release of PNS gastric floating sustained-release tablets was stable, the sustained release effect is better, it can effectively improve the bioavailability of the preparation, and has a certain correlation in vivo and in vivo drug release process.

关 键 词：胃漂浮缓释片 三七总皂苷 体内释药 药动学 

分 类 号：R285.5[医药卫生—中药学]