N-苯基硫脲衍生物新的合成方法  

Synthesis of N-Phenylthiourea Derivatives

作　　者：刘海灵 刘媛 王香凤 徐海燕 LIU Hai-ling;LIU Yuan;WANG Xiang-feng;XU Hai-yan(Analytical ＆ Testing Center,Beijing Normal Univcrsity,Beijing 100875,China)

机构地区：[1]北京师范大学分析测试中心,北京100875

出　　处：《化学试剂》2017年第12期1347-1351,共5页Chemical Reagents

基　　金：横向课题资助项目(KJHX2015286)

摘　　要：硫脲衍生物是一类具有强烈生理和药理活性的有机试剂。以乙酰乙酰苯胺和硫氰酸铵为原料,在无催化剂的条件下,开发了一种合成标题化合物的方法。结果表明,乙酰乙酰苯胺无论是具有吸电子取代基还是给电子取代基,反应都可以顺利进行。合成了11种硫脲衍生物,所得产物的分离产率为81%~94%,并利用质谱、核磁共振波谱、红外光谱对所合成的化合物进行了表征。Thiourea derivatives are a class of organic reagents possessing important biological and pharmaceutical activities.In this work,a catalyst-free method for the synthesis of N-phenylthiourea derivatives was developed directly from acetoacetanilides and ammonium thiocyanate.Investigation of representative acetoacetanilides demonstrates that the transformation is feasible whether the substituents are electron-donating or electron-withdrawing groups. The desired N-phenylthiourea derivatives were obtained with81% ~ 94% isolated yields and confirmed by MS,NMR and IR.

关 键 词：乙酰乙酰苯胺 硫氰酸铵 N-苯基硫脲衍生物 

分 类 号：O622.7[理学—有机化学]