2,5-二(2-(4-吡啶基)乙炔基)苯胺的合成  

Synthesis of 2,5-bis [2-(4-pyridinyl) Ethynyl]-benzenamine

作　　者：邱佳[1] 梁光平 

机构地区：[1]遵义医药高等专科学校,贵州遵义563006

出　　处：《广东化工》2017年第23期53-53,64,共2页Guangdong Chemical Industry

摘　　要：2,5-二(2-(4-吡啶基)乙炔基)苯胺是一个重要的化工中间体,在环境工程以及天然药物化学领域具有广泛的应用前景,但现有合成方法较为繁琐。本文以2,5-二溴苯胺和4-乙炔基吡啶盐酸盐为起始原料,通过Sonogashira偶联反应一步反应可直接获得目标产物,其结构经高分辨质谱和核磁得以确证。该方法原料价廉易得,操作步骤简单,反应总收率62.3%。2,5-bis[2-（4-pyridinyl）ethynyl]-benzenamine is an important chemical intermediate. It has a very wide application prospect in environmental engineering and natural medicine chemistry, but the existing synthesis method is more cumbersome. In this paper, 2,5-bis[2-（4-pyridinyl）ethynyl]-benzenamine was synthesized by Sonogashira coupling reaction with 2,5-dibromaniline and 4-ethynylpyridine hydrochloride as the starting materials, and its structure was confirmed by high-resolution mass spectrometry and nuclear magnetic resonance. The synthetic route is only one chemical step with the total yield 62.3 %, and the price of raw materials is low and easy to obtain.

关 键 词：2 5-(2-(4-吡啶基)乙炔基)苯胺 Sonogashim反应 合成 

分 类 号：TQ246.31[化学工程—有机化工]