Th17/Treg失衡与肺部疾病发病机制的研究进展  被引量:11

The research progress of Th17/Treg imbalance in pathogenesis of pulmonary disease

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作  者:张奕 张兰英[1] 欧阳瑶[1] 

机构地区:[1]遵义医学院附属医院呼吸一科,贵州遵义563000 [2]贵州省遵义市第二人民医院内科,贵州遵义563000

出  处:《中国医药导报》2017年第35期20-24,共5页China Medical Herald

基  金:国家自然科学基金资助项目(81460008)

摘  要:具有促炎作用的辅助性T细胞17(Th17)及维持免疫耐受的调节性T细胞(Treg)是体内重要的两种免疫细胞,在分化上关系密切且功能上相互制约,存在一种动态平衡。两者失衡会导致自身免疫性疾病、慢性感染疾病、肿瘤。近年来随着呼吸系统常见疾病的不断深入研究,发现Th17细胞、Treg细胞与肺部疾病的发病机制有关,Th17/Treg失衡参与了慢性阻塞性肺疾病、肺癌、肺结节病及哮喘的免疫调节机制。本文阐述了Th17细胞、Treg细胞以及Th17/Treg失衡在上述肺部相关疾病中的研究进展。T helper 17 cells (Th17) with pro-inflammatory activity and regulatory T cells (Treg) cells that maintain immune tolerance are important immune cells in humans. They are closely related in differentiation and functional constraints to each other, and there is a dynamic balance. Imbalance between the two can lead to autoimmune diseases, tumors, persistent infection diseases. In recent years, with the study of the common diseases of the respiratory system deeply, of Th17 cells and Treg cells were found to be associated with more lung disease pathogenesis, immune imbalance of Th17/Treg cells in patients with chronic obstructive pulmonary disease, lung cancer, pulmonary sarcoidosis and asthma among the adjustment mechanism. This article describes the progress of Th17 cells, Treg cells and Th17/Treg imbalance in lung related diseases.

关 键 词:辅助性T细胞17 调节性T细胞 肺部疾病 研究进展 

分 类 号:R56[医药卫生—呼吸系统]

 

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