肛舒洗液用于混合痔剥扎术后康复的临床效果  

Clinical effect of Gangshu Lotion in rehabilitation of mixed hemorrhoid after operation

作　　者：肖深 秦建平[1] 

机构地区：[1]遵义医学院附属医院中医科,贵州遵义563000

出　　处：《中国医药导报》2017年第35期106-109,共4页China Medical Herald

基　　金：贵州省中医药管理局项目(D-302)

摘　　要：目的探讨肛舒洗液在混合痔剥扎术后康复中的安全性和有效性,观察其对血清中前列腺素E2(PGE2)含量变化的影响,阐明其可能的镇痛机制。方法选取2017年1~7月遵义医学院附属医院收治的60例混合痔患者作为研究对象,采用随机数字表法分为中药组和西药组,每组各30例。利用外剥内扎术对两组进行治疗,中药组术后利用自拟肛舒洗液进行熏洗、坐浴,西药组术后利用聚维酮碘溶液熏洗、坐浴,均处理至创面痊愈。评定患者术后1、3、5 d创面疼痛、水肿,便血情况,并用酶联免疫吸附法测定患者血清PGE2的水平。结果中药组水肿消退时间、创面完全愈合时间均短于西药组,差异有统计学意义(P<0.05)。术后第5天,中药组出血评分明显降低且低于西药组,差异有统计学意义(P<0.05)。与术后第1天比较,术后第3天及第5天两组疼痛评分及血清PGE2水平均升高,而中药组的升高幅度均低于西药组,差异有统计学意义(P<0.05)。结论肛舒洗液可安全有效促进混合痔剥扎术后康复,其镇痛机制可能与降低患者体内PGE2的水平有关。Objective To investigate the safety and efficacy of Gangshu Lotion in rehabilitation of mixed hemorrhoid after operation, to observe its influence on the change of prostaglandin E2 （PGE2） content in serum, in order to clarify its possible analgesic mechanism. Methods Sixty patients with mixed hemorrhoid admitted to Affiliated Hospital of Zunyi Medical College from January to July in 2017 were selected and divided into Chinese medicine group and western medicine group by random number table, with 30 cases in each group. Both groups were treated by Milligan-Morgan operation. After operation, the Chinese medicine group was treated by fumigation and sitz bath with self-made Gangshu Lotion. After operation, the western medicine group was treated by fumigation and sitz bath with povidone, both treatment until the wounds healed. All patients were assessed about wound pain, edema, hemafecia at 1 day, 3 days, 5 days after operation, and the levels of serum PGE2 were measured by enzyme-linked immunosorbent assay. Results The regression time of edema and wound healing of the Chinese medicine group were shorter than those of the western medicine group, with statistically significant difference （P 〈 0.05）. 5 days after operation, the bleeding score of the Chinese medicine group was lower than that of the western medicine group, with statistically significant difference （P 〈 0.05）. The scores of pain and the levels of PGE2 in the two groups at 3 days and 5 days after operation were significantly higher than those at 1 day after operation, and those of the Chinese medicine group were lower than those of the western medicine group, with statistically significant difference （P 〈 0.05）. Conclusion Gangshu Lotion can effectively improve rehabilitation of mixed hemorrhoid after operation. The analgesic mechanism may be related to the decrease of the levels of serum PGE2.

关 键 词：肛舒洗液 混合痔 术后 临床效果 

分 类 号：R266[医药卫生—中医外科学]