动态监测血浆(1,3)-β-D-葡聚糖含量对评价侵袭性真菌感染患者药物疗效的价值  

The value of dynamic monitoring of plasma(1,3)-beta-D-glucan content in evaluating the efficacy of drugs in patients with invasive fungal infection

作　　者：温冬华 刘钰华 谭坚 黄常坚 李军 

机构地区：[1]广西壮族自治区梧州市人民医院药学部,广西梧州543000 [2]广西壮族自治区梧州市人民医院检验科,广西梧州543000 [3]广西壮族自治区梧州市人民医院神经外科,广西梧州543000

出　　处：《中国医药导报》2017年第35期110-113,117,共5页China Medical Herald

基　　金：广西壮族自治区梧州市科学研究与技术开发计划项目(201202050)

摘　　要：目的探讨(1,3)-β-D-葡聚糖动态检测对评价侵袭性真菌感染的抗真菌药物疗效的价值。方法应用真菌(1,3)-β-D-葡聚糖检测试剂盒定量检测梧州市人民医院2013年3月~2017年3月42例侵袭性真菌感染患者的血浆(1,3)-β-D-葡聚糖的含量,并结合临床资料进行分析。结果经抗真菌治疗后,40例患者血浆(1,3)-β-D-葡聚糖浓度显著降低,其中有5例患者血浆(1,3)-β-D-葡聚糖先小幅度上升后再下降至正常水平。此外,2例患者血浆(1,3)-β-D-葡聚糖未降至正常水平。结论对侵袭性真菌感染的患者进行血浆(1,3)-β-D-葡聚糖动态检测是有效评价抗真菌药物疗效的指标,可指导临床合理应用抗真菌药物。Objective To investigate the value of （1,3）-beta-D-glucan dynamic detection in evaluating the efficacy of antifungal drugs in invasive fungal infections. Methods The levels of （1,3）-beta-D-glucan from 42 patients with invasive fungal infections were detected by fungi （1,3）-beta-D-beta-glucan assay kit, who were treated in the People′s Hospital of Wuzhou from March 2013 to March 2017, with analyzing the clinical data of the cases. Results After antifungal treatment, the levels of plasma （1, 3）-beta-D-dextran were significantly reduced in 40 patients, of which the levels of 5 patients decreased to normal levels after a small increase. Besides, the levels of 2 patients were not decreased to normal levels. Conclusion Dynamic detection of plasma （1,3）-beta-D-glucan in patients with invasive fungal infection is an effective indicator to evaluate the efficacy of antifungal drugs, which can guide the rational use of antifungal drugs in clinic.

关 键 词：(1 3)-β-D-葡聚糖 真菌感染 抗真菌药物 

分 类 号：R519[医药卫生—内科学]