地佐辛注射液治疗急性结石性肾绞痛的临床效果  

Clinical effect of dezocine injection on acute calculous renal colic

作　　者：杨雍[1] 吕汝琦[1] 刘纪宁[1] 冷晓辉[1] 

机构地区：[1]四川省绵阳市中心医院急诊科,621000

出　　处：《中国医药》2017年第12期1865-1868,共4页China Medicine

摘　　要：目的观察地佐辛注射液治疗急性结石性肾绞痛的临床效果及安全性。方法选择2015年6月至2016年9月在四川省绵阳市中心医院急诊科就诊的输尿管结石性肾绞痛患者286例。所有患者完全随机分为对照组和观察组，各143例。对照组患者给予盐酸哌替啶注射液50mg肌内注射，观察组患者给予地佐辛注射液5mg肌内注射。比较2组患者治疗前和治疗后30、60min疼痛口述分级评分法（VRS）评级、疼痛视觉模拟量表（VAS）评分、总有效率和不良反应情况。结果2组间治疗前和治疗后30、60minVRS评级比较，差异均无统计学意义（均P〉0．05）。2组内治疗后30、60minVRS评级低于治疗前[对照组：（1．7±0．4）、（1．6±0．3）级比（2．4±0．7）级；观察组：（1．7±0．4）、（1．5±0．5）级比（2．5±0．7）级]，差异均有统计学意义（均P〈0．05）。2组间治疗前和治疗后30、60minVAS评分比较，差异均无统计学意义（均P〉0．05）。2组内治疗后30、60minVAS评分低于治疗前[对照组：（2．7±0．8）、（2．6±0．5）分比（7．7±0．7）分；观察组：（3．1±0．6）、（2．8±0．6）分比（7．6±0．7）分]，差异均有统计学意义（均P〈0．05）。观察组总有效率与对照组比较，差异无统计学意义（P〉0．05）。观察组不良反应发生率低于对照组[4．9％（7／143）比20．3％（29／143）]，差异有统计学意义（P〈0．05）。结论地佐辛注射液治疗急性结石性肾绞痛有较好的镇痛效果，且不良反应少。Objective To analyze the clinical curative effect and safety of dezocine injection on acute calculous renal colic. Methods Totally 286 patients with ureteral calculous renal colic in the Department of Emergency of Mianyang Central Hospital in Sichuan Province from June 2015 to September 2016 were randomly divided into control group and observation group, with 143 cases in each group. The control group was treated with 50 mg pethidine hydrochloride intramuscular injection; the observation group patients was treated with 5 mg dezocine intramuscular injection. Grade of the Vertal Rating Scale （ VRS）, score of the Visual Analogue Scale （VAS） for pain, the total effective rate and adverse reactions were analyzed. Results The VRS grade had no significant difference between groups before and 30, 60 min after treatment （ P 〉 0. 05 ）. The VRS grade 30 and 60 min after treatment was significantly lower than that before treatment [ control group ： （ h 7 ± 0. 4）, （ 1.6 ± 0. 3 ） vs （2.4 ± 0. 7） ; observation group ： （ h 7± 0. 4）, （ h 5± 0. 5 ） vs （2.5±0. 7 ） ] （ P 〈 0. 05 ）. The VAS score had no significant difference between groups before and 30, 60 min after treatment （P 〉 0. 05 ）. The VAS score 30 and 60 rain after treatment was significantly lower than that before treatment [ control group ： （ 2. 7 ± 0. 8 ）, （ 2. 6 ± 0. 5 ） points vs （7.7 ± 0. 7） points ; observation group ： （ 3.1 ± 0. 6 ）, （ 2. 8 ± 0. 6 ） points vs （ 7.6 ±0. 7 ） points 1 （P 〈 0. 05 ）. The total effective rate had no significant difference between groups （P 〉 0. 05 ）. The incidence of adverse reactions in observation group was significantly lower than that in control group[ 4. 9% （7/143） vs 20. 3% （29/143） 1 （P 〈 0. 05）. Conclusion Dezocine injection has a good and safe analgesic effect on acute calculous renal colic.

关 键 词：急性肾绞痛 地佐辛 盐酸哌替啶注射液 

分 类 号：R692[医药卫生—泌尿科学]