2型糖尿病患者血小板反应蛋白-1与颈动脉粥样硬化的关系  

The relationship between the thrombospondin-1 and the carotid atherosclerosis in patients with type 2 diabetic

作　　者：边志颖[1] 胡艳云[1] 王君[1] 孙倩[1] 郄海静 赵新翠 肖艳新[1] 尹超[1] 

机构地区：[1]保定市第一中心医院内分泌三科,071000

出　　处：《天津医药》2017年第12期1316-1319,共4页Tianjin Medical Journal

基　　金：河北省2016年度医学科学研究重点课题计划(20160006)

摘　　要：目的探讨2型糖尿病患者血清血小板反应蛋白-1(TSP-1)与颈动脉粥样硬化及其相关指标之间的关系。方法选取2型糖尿病患者101例,根据是否合并颈动脉粥样硬化分为单纯2型糖尿病组(A组,n=52)、2型糖尿病合并颈动脉粥样硬化组(B组,n=49);另选50例体检健康者为正常对照组(C组,n=50)。检测各研究对象的TSP-1、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(Hb A1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、纤维蛋白原(Fib)、同型半胱氨酸(Hcy)等指标在3组间的差异,分析TSP-1与其他相关指标的相关性。结果 3组舒张压(DBP)、体质量指数(BMI)差异无统计学意义(P>0.05)。B组收缩压(SBP)高于A组与C组(P<0.01),但A组与C组之间比较差异无统计学意义(P>0.05)。3组间TC、TG、HDL-C差异无统计学意义(P>0.05)。、B组、A组及C组间TSP-1、Hcy依次增高,差异均有统计学意义(P<0.05)。3组间FPG、Hb A1c、Fib、FINS及LDL-C差异有统计学意义(P<0.05)。TSP-1与FPG、FINS、Hb A1c、Fib、Hcy呈正相关(r值分别为0.585、0.341、0.701、0.409、0.351,均P<0.05)。线性回归分析显示,TSP-1受FINS、Hb A1c及Fib的影响,其中Hb A1c影响较大。结论 TSP-1与糖尿病大血管病变发生、发展有关,对早期发现、早期治疗糖尿病大血管病变、延缓疾病进展具有很好的临床价值。Objective To investigate the relationship between the thrombospondin-1 （TSP-1） and carotid atherosclerosis and its related indicators in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 101 T2DM patients were divided into T2DM group （A group, n = 52） and T2DM with carotid artery atherosclerosis group （B group, n = 49） according to whether complicated with carotid artery atherosclerosis, and 50 normal healthy persons were used as the normal group （C group , n=50）. The TSP-1 and other clinical indicators were detected including fasting blood sugar （FPG）, fasting insulin （FINS）, glycosylated hemoglobin （HbA1c）, triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, fibrinogen （Fib） and homocysteine （homocysteine）. The differences between TSP-1 and other related indicators were analyzed. Results There were no significant differences in diastolic blood pressure （DBP） and body mass index （BMI） between the 3 groups （P〉0.05）. The level of systolic blood pressure （SBP） was significantly higher in group B than that of group A and group C （P〈0.01）, but there was no significant difference between group A and group C （P〉0.05）. There were no significant differences in TC, TG and HDL-C between three groups （P〉0.05）. The values of TSP-1 and Hcy were increased sequentially in group B, group A and group C （P 〈 0.05）. There were significant differences in FPG, HbA1c, Fib, FINS and LDL-C between three groups （P〈0.05）. TSP-1 was positively correlated with FPG, FINS, HbA1c, Fib and Hcy （r= 0.585, 0.341, 0.701, 0.409 and 0.351, P 〈 0.05）. Linear regression analysis showed that TSP-1 was affected by FINS, HbA1c and Fib, and HbA1c was more important. Conclusion TSP-1 is associated with the occurrence and development of diabetic macrovascular complications. It has good clinical value for early detection, early treatment and delaying the

关 键 词：糖尿病 2型 血小板反应蛋白-1 颈动脉粥样硬化 同型半胱氨酸 

分 类 号：R587.1[医药卫生—内分泌]