秦七风湿胶囊的镇痛作用及其对免疫功能的影响  

Analgesic Effect of Qinqi Rheumatism Capsule and Its Influence on Immune Function

作　　者：王梅 唐志书 周瑞 宋忠兴 

机构地区：[1]陕西中医药大学附属医院,咸阳712000 [2]陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室,咸阳712083

出　　处：《世界中医药》2017年第11期2740-2743,2748,共5页World Chinese Medicine

基　　金：国家"十二五"重大新药创制科技重大专项(2011ZX09401-308-036);陕西省重点科技创新团队(2012KTC-20);陕西省科技资源开放共享平台项目(2015FWPT-01)

摘　　要：目的:研究秦七风湿胶囊的镇痛作用及其对免疫功能的影响。方法:镇痛实验采用醋酸扭体法、小鼠甩尾法、大鼠足趾压痛实验及小鼠尾压痛试验,观察秦七风湿胶囊的镇痛作用;免疫实验采用小鼠免疫器官重量实验、溶血素抗体实验、二硝基氟苯所致小鼠迟发型超敏反应实验模型,观察其对免疫功能的影响。结果:研究发现秦七风湿胶囊能减少醋酸所致小鼠扭体反应的次数,提高小鼠对热刺激痛阈值,还可减轻大、小鼠压痛的致痛程度,说明该药具备良好的镇痛作用;研究还发现秦七风湿胶囊对小鼠溶血素抗体生成和由二硝基氟苯引起的迟发型超敏反应均有抑制作用,说明秦七风湿胶囊对机体非特异性免疫和细胞免疫功能具有较强的抑制作用。结论:秦七风湿胶囊具有较强的镇痛作用,并具有抑制免疫功能的作用,为其临床治疗类风湿关节炎提供了药理学依据。Objective： To study the analgesic effect of Qinqi Rheumatism Capsule and its effect on immune function through various animal models. Methods： The analgesic effects of Qinqi Rheumatism Capsule were investigated on animal models by acetic acid twisting method,the method of flicking tail,toes pain tenderness and tail pain tenderness test; The influence of Qinqi Rheumatism Capsule on the immune function in mice was investigated by mouse immune organ＇ weight test,serum hemolysin antibody test and dinitrofluorobenzene（ DNFB）-induced delayed-type hypersensitivity（ DTH） model. Results： Qinqi Rheumatism Capsule significantly reduced the number of acetic acid-induced writhing,improved the thermal pain threshold in mice,and alleviated the pain degree in toes and tail pain tenderness,indicating that the analgesic effect of Qinqi Rheumatism Capsule; In addition,it could also inhibit the production of hemolysin antibody and delayed-type hypersensitivity induced by DNFB,suggesting the inhibitory effect of Qinqi Rheumatism Capsule on innate immune and cellular immune function. Conclusion： Qinqi Rheumatism Capsule has obvious analgesic and inhibitory effect on immune function. This study provides a pharmacological basis for Qinqi Rheumatism Capsule＇ s clinical treatment of rheumatoid arthritis.

关 键 词：秦七风湿胶囊 镇痛作用 免疫功能 

分 类 号：R392[医药卫生—免疫学]