肠道营养素感知系统和血糖控制关系研究进展  

Advances in the Relationship between Intestinal Nutrient Perception System and Blood Glucose Control

作　　者：夏智红 朱世飞 萧文泽 张鹏 周里钢 

机构地区：[1]上海市浦东医院,上海200120

出　　处：《辽宁中医药大学学报》2017年第12期83-85,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81370932);上海市浦东新区卫生系统糖尿病与肥胖外科重点学科群资助项目(PWZxq2014-08)

摘　　要：在肠道内分泌细胞中存在特定营养感知系统,能够感知肠道内容物,该系统被激活后能够释放胃肠激素。在这些所释放的肽类激素当中,抑胃肽和胰高血糖素样肽-1在维持人体葡萄糖动态平衡中起着独特的作用,在调节代谢的同时,使得β细胞发挥其适宜的功能。该文重点阐述肠道感知营养的过程及其在糖尿病的发生中所起的作用。Nutrient-specific sensor systems in enteroendocrine cells detect intestinal contents and cause gut hormone release upon activation.Among these peptide hormones,the incretins glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 are of particular interest by their role in glucose homeostasis,metabolic control and for proper β-cell function.This review focuses on intestinal nutrientsensing processes and their role in health and disease.

关 键 词：减重手术 糖尿病 胃肠激素 胰岛素 肠促胰素 

分 类 号：R587.1[医药卫生—内分泌]