中成药辅助干预治疗某高校结核菌素试验阳性患者疗效分析  

Study on the Effect of Auxiliary Intervention of Chinese Medicine in the Treatment of Positive Tuberculin Test in One Collage

作　　者：杨柳[1] 赵小红[2] 徐欣雨 周学标[1] 刘婷 

机构地区：[1]陕西国防工业职业技术学院校医院,陕西西安710302 [2]陕西省人民医院,陕西西安710068

出　　处：《辽宁中医药大学学报》2017年第12期127-129,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：陕西省教育厅专项科研计划项目(16JK1062)

摘　　要：目的 :探讨中成药辅助治疗结核菌素试验阳性抗结核预防治疗过程中胃肠道反应的疗效分析。方法 :本次临床观察时间为2013年3月15日—2016年5月8日,选取我校体检时发现结核菌素试验强阳性,且经抗结核预防治疗过程中出现胃肠道反应患者40例,在医学伦理委员会监督下,按就诊顺序随机分为对照组(n=20)和干预组(n=20),对照组常规治疗基础上给予安慰剂;干预组在常规治疗基础上给予玉屏风散颗粒口服,5 g/次,3次/d,持续治疗2周。治疗期间观察胃肠道反应消失时间、抗结核药物应用时间;治疗前后采血测定血清T淋巴细胞亚群,进行随访评价生活质量综合评估问卷(Quality of life comprehensive assessment questionnaire,GQOL-74)、焦虑自评量表(self-rating anxiety scale,SAS)和抑郁自评量表(self-rating depression scale,SDS)。结果 :对照组在胃肠道反应消失时间、抗结核药物应用时间上,均高于干预组,有统计学差异(P<0.05)。治疗后对照组和干预组CD_3^+分别为69.19%±4.28%、72.33%±4.51%,CD_4^+分别为40.19%±3.04%、43.21%±3.15%,CD_4^+/CD_8^+分别为2.01±0.27、2.24±0.22,SAS量表分别为53.20±9.56、43.19±9.17,SDS量表分别为42.12±9.34、33.16±8.52,GQOL-74量表分别为69.82±11.29、82.15±12.34,对照组上述指标与干预组比较,有统计学意义(P<0.05)。结论 :中成药辅助治疗有利于缩短结核菌素试验阳性抗结核过程胃肠道反应缓解时间,提高机体免疫功能和生活质量。Objective ：To investigate the effect of auxiliary intervention of Chinese medicine in the treatment of positive tuberculin test in one collage.Methods ：40 patients with gastrointestinal reactions of strongly positive tuberculin test in our collage form 2013.3.15 to 2016.5.8 were selected and randomly divided into 2 groups,20 cases each.The control group received conventional therapy with placebo,and the study group received conventional therapy with Yupingfeng San 5 mg,tid,and 2 groups were treated for 2 weeks.Disappearance time of gastrointestinal reaction and application time of anti tuberculosis drugs were recorded,and blood samples were collected to determine the levels of T helper cells,and GQOL-74,SAS and SDS were also recorded.Results ：Compared with the control group,levels of the disappearance time of gastrointestinal reaction and the time of anti tuberculosis drug application in the study group were lower（P〈0.05）.After treatment,levels of CD3^＋ in the study group and the control group were（69.19%±4.28%）,（72.33%±4.51%）,CD4^＋ were（40.19%±3.04%）,（43.21%±3.15%）,CD4^＋/CD8^＋ were（2.01±0.27）,（2.24±0.22）,scores of SAS were（53.20±9.56）,（43.19±9.17）,scores of SDS were（42.12±9.34）,（33.16±8.52）,and scores of GQOL-74 were（69.82±11.29）,（82.15±12.34）,and all above in 2 groups had statistical significance（P〈0.05）.Conclusion ：Auxiliary intervention of Chinese medicine in the treatment of positive tuberculin test in one collage was beneficial to shorten the remission time of gastrointestinal reaction in tuberculin positive anti tuberculosis process,and improved the immune function and quality of life.

关 键 词：中成药辅助治疗 结核菌素试验阳性 抗结核 胃肠道反应 免疫功能 

分 类 号：R52[医药卫生—内科学]