COPD患者HMGB1、免疫细胞和纤维蛋白原联合检测的临床意义  

Clinical significance of combined detection of serum levels of HMGB1,immune cells and fibrinogen in COPD patients

作　　者：周广辉 冯艳[1] 陈如华[1] 丁辉[1] ZHOU Guang-Hui;FENG Yan;CHEN Ru-Hua;DING Hui(Department of Respiratory Medicine, Yixing People＇s Hospital, Yixing 214200, China)

机构地区：[1]江苏省宜兴市人民医院呼吸内科,江苏宜兴214200

出　　处：《转化医学电子杂志》2017年第12期17-19,共3页E-Journal of Translational Medicine

基　　金：国家自然科学基金(81500049);江苏省卫计委科教强卫项目(QNRC2016210);江苏省卫生厅医改科研课题基金(YG201408)

摘　　要：目的:探讨高迁移率蛋白1(HMGB1)、免疫细胞联合纤维蛋白原(FIB)、中性粒细胞/淋巴细胞水平(NLR)在COPD病情严重程度及预后中的作用.方法:选取2012-10/2016-04江苏省宜兴市人民医院呼吸内科收治的COPD患者80例作为研究对象,按照治疗效果分为COPD缓解组(n=40)及非缓解组(n=40),依据肺功能分轻-中度组(n=30),重-极重度组(n=25),以健康体检者共40例作为对照组.观察相关血清学指标与COPD治疗效果、肺功能指标的关系,并对患者进行3年随访,观察其与预后的关系.结果:COPD患者HMGB1、FIB和NLR水平明显高于健康体检者,差异具有统计学意义(P<0.05);COPD缓解组HMGB1、FIB和NLR水平低于非缓解组,差异具有统计学意义(P<0.05);COPD患者肺功能重-极重度组HMGB1、FIB和NLR表达较高,差异具有统计学意义(P<0.05);HMGB1、FIB和NLR高水平的COPD患者死亡率较高,差异具有统计学意义(P<0.05).结论:HMGB1、FIB和NLR联合检测对判断COPD疾病严重程度、肺功能分级和病情预后具有重要临床意义.AIM： To investigate the effect of high mobility group box 1 （HMGBI）, immune cell combined with fibrinogen （FIB）, neutrephil-to-lymphocyte ratio （NLR） on the severity degree and prognosis of COPD patients. METHODS： A total of 80 COPD patients admitted into Department of Respiratory Medicine, Yixing People＇s Hospital were selected as research objects. According to the treatment effect, the patients were divided into remission group and no-remission group, with 40 patients in each group. According to lung function, the patients were divided into mild to moderate group （ n = 30）, severe to profound group （ n = 25）. A total of 40 healthy patients were treated as control group. The relationship between serum indexes, treatment effect and lung function indices of COPD were analyzed. The patients were followed for three years and prognosis of COPD patients were observed. RESULTS： The levels of HMGB1, FIB and NLR in COPD patients were higher than those of normal people, with statistically significant differences （ P 〈 0. 05 ）. The levels of HMGB1, FIB and NLR in remission group were lower than those of no-remission group, with statistically significant differences （P〈0.05）. The levels of HMGB1, FIB and NLR in severe to profound group were higher than those of mild to moderate group, with statistically significant differences （ P 〈 0.05 ）. The COPD patients with high levels of HMGB1, FIB and NLR suffered high mortality, with statistically significant differences （ P 〈 0. 05 ）. CONCLUSION： Combined detection of serum levels of HMGB1, FIB and NLR is significant to judge the severity degree, lung function and the prognosis of COPD patients.

关 键 词：慢性阻塞性肺疾病 高迁移率蛋白1 纤维蛋白原 

分 类 号：R563.9[医药卫生—呼吸系统]