中性粒细胞胞外诱捕网及相关疾病的研究进展  

Current research development of neutrophil extracellular traps related diseases

作　　者：查才军 高飞[1] 张文静[1] 刘彦虹[1] Zha Caijun;Gao Fei;Zhang Wenjing;Liu Yanhong(Department of Clinical Laboratory, the Second Affiliated Hospital,Harbin Medical University,Harbin 150086, China)

机构地区：[1]哈尔滨医科大学附属第二医院检验科,150086

出　　处：《国际免疫学杂志》2017年第6期659-663,共5页International Journal of Immunology

基　　金：国家自然科学基金（81541031）

摘　　要：中性粒细胞是机体先天性免疫的主力军。中性粒细胞胞外诱捕网（nertrophil extracellular traps，NETs）是中性粒细胞在适宜刺激下释放到胞外的一种纤维网格样结构。NETs的形成是中性粒细胞杀灭胞外病原体的一种有别于坏死和凋亡的新型细胞死亡方式，称为NETosis。研究表明包括自身抗体、肿瘤细胞在内的多种刺激物均可促发中性粒细胞产生NETs，并在相应疾病中发挥特定作用。因而NETs在炎症、血栓、自身免疫、糖尿病、囊性纤维化、肿瘤等疾病中的最新研究进展具有重要意义。Neutrophils are the predominant cell population in innate immunity. Neutrophil extracellular traps （NETs） are web like structures formed by the materials released by neutrophils under appropriate stimulation. NETosis,is a novel cell death program executed by neutrophils in order to kill pathogen. NETosis is different from necrosis and apoptosis. The latest Studies have found that stimuli such as autoantibodies and tumor cells could also induce the formation of NETs, and NETs play a key role in the pathogenesis of those diseases. This review presents the latest data on NETs related diseases, such as inflammation, thrombosis, autoimmunity diseases, diabetes mellitus, cystic fibrosis, and tumor.

关 键 词：中性粒细胞胞外诱捕网 炎症 血栓 自身免疫 肿瘤 

分 类 号：R392[医药卫生—免疫学]