自身免疫与心血管疾病关系的研究进展  

The research advance of the relationship between autoimmunity and cardiovascular diseases

作　　者：张金花[1] 张葵[1] Zhang Jinhua;Zhang Kui(Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing 210008, China)

机构地区：[1]南京大学医学院附属鼓楼医院检验科,210008

出　　处：《国际免疫学杂志》2017年第6期688-692,共5页International Journal of Immunology

摘　　要：尽管医疗水平在不断地提高，心血管疾病的患病率和死亡率仍居高不下。心血管疾病仍然是当今社会威胁人类健康的一个重大难题。越来越多的研究表明，免疫反应参与了多种心血管疾病的发生发展，如扩张型心肌病、心肌梗死、心力衰竭、肥厚性心肌病等，并且在患者血清中检测到了特定的自身抗体，推测这些与心血管疾病相关的自身抗体可能参与心室重塑和／或心衰的病理生理过程。Although with the development of medicine, the morbidity and mortality rates of cardiovascular diseases are still increasing. More and more studies indicated that immune response participates in the pathophysiology of cardiovascular diseases, such as dilated eardiomyopathy, myocardial infarction, heart failure, hypertrophic cardiomyopathy. The presence of autoantibodies against specific antiges in the serum of the patients with cardiovascular diseases indicates that autoimmunity takes part in the process of ventricular remodeling and（or） heart failure. This review will summarize the investigations about the role of autoantibodies among cardivascular disease.

关 键 词：自身免疫 心血管疾病 自身抗体 

分 类 号：R54[医药卫生—心血管疾病]