尼古丁微生物降解代谢机制和应用的研究进展  

Research Development of Nicotine Degrading Mechanism in Microorganisms and Their Applications

作　　者：李晓华[1] 梅枫 孔雯[1] 李阳[1] 马婷婷[1] 皮婷[1] 

机构地区：[1]中南民族大学生命科学学院生物技术国家民委重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2017年第4期27-35,共9页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(31070087;30570046);湖北省自然科学基金重点资助项目(2011CDA079;2008CDB076);中央高校基本科研业务费专项资金资助项目(YCZW15104;CZW16005)

摘　　要：为进一步了解利用生物降解消除环境中尼古丁污染的最有前景的方法,综述了国内外尼古丁降解微生物、尼古丁降解代谢途径(真菌的去甲基化途径、革兰氏阳性菌的吡啶和吡咯途径、革兰氏阴性菌吡啶与吡咯途径的混合途径)、降解基因簇及其在环保和药学领域的应用,旨在为微生物降解尼古丁的深入研究和应用提供参考.To learn about the most promising way of biodegradation to eliminate environmental nicotine pollution,this article gave an overview about the development of nicotine degrading microorganisms,degradation pathways（demethylation pathway in fungi,pyridine and pyrrolidine pathway in gram-positive bacteria,and variant pathway of pyridine and pyrrolidine in gram-negative bacteria）,degradation gene clusters and their application in environmental protection and pharmacology,which may serve as a reference to guide the further study and application of nicotine degrading microorganisms.

关 键 词：尼古丁 微生物降解 代谢途径 应用 

分 类 号：Q939[生物学—微生物学]