化橘红、连翘、当归混合挥发油提取及包合工艺研究  

Study on extraction and inclusion process of mixed volatile oil from pummelo peel,forsythia and angelica

作　　者：王文平[1] 倪健[1] 杨春静[1] 张欣[1] 王庆玲[1] 董晓旭[1] 冷新[1] 尹兴斌[1] 冯淬灵[2] 

机构地区：[1]北京中医药大学中药学院,硕士研究生100102 [2]北京大学人民医院中医科

出　　处：《环球中医药》2017年第12期1456-1459,共4页Global Traditional Chinese Medicine

基　　金：北京中医药大学协同创新建设计划(2013-XTCX-03);北京市科技计划"十病十药"研发项目(Z020071620099)

摘　　要：目的优选芪蛭益肺颗粒中化橘红、连翘、当归混合挥发油提取及包合的工艺条件。方法以混合挥发油的得率为指标,单因素试验考察混合油的提取工艺;采用饱和水溶液法,进行L_9(3~4)正交实验,优选挥发油的包合工艺。并采用显微呈像分析,X射线衍射法对包合物进行表征。结果挥发油最优提取工艺为:不浸泡,加12倍量水,提取10小时;最佳包合工艺为:油(m L)∶β-CD(g)∶水(m L)比例为1∶10∶100,包合温度为40℃,包合时间为3小时。显微镜法、X射线衍射法表明包合物形成,包合状态良好。结论本实验优化的挥发油提取及包合工艺稳定可行,可为制剂生产提供支撑性数据。Objective To optimize the process of extraction of mixed volatile oil from pummelo peel, forsythia, angelica and inclusion of β-cyclodextrin （β-CD） of Qizhi Yifei granule. Method Yield ratio of volatile oil was regarded as evaluation index, single factor experiments were used to study the extraction process of volatile oil. Saturated aqueous solution was used to the L9 （3^4） orthogonal experiments to reach the best inclusion process optimization. And the microscopic imaging analysis, X-ray scattering technology was adopted to character the inclusion compound. Results The optimum extraction process of volatile oil was adding 12-folds water, 10 hours for each time and without soaking. The optimum conditions of inclusion process were as follows： mixed volatile oil（mL） ： β-CD（g） ： water （mL） ratio was 1 ： 10 ： 100; inclusion temperature was 4023; the inclusion time were 3 hours. Microscopic imaging analysis and X-ray scattering technology proved the inclusion compound had been formed. Conculsion Optimal extraction and inclusion process of the study was feasible and stable, which can provide certain supporting data for preparation.

关 键 词：化橘红 连翘 当归 混合挥发油 提取包合 

分 类 号：R284[医药卫生—中药学]