鼻炎脱敏方联合氯雷他定治疗过敏性鼻炎的临床疗效观察  

Effects of rhinitis desensitization prescription combined with loratadine in treatment of allergic rhinitis

作　　者：佘文胜[1] 皮本元 

机构地区：[1]鄂州市中心医院耳鼻咽喉科,湖北鄂州436000

出　　处：《西南国防医药》2017年第12期1316-1318,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探究鼻炎脱敏方雾化吸入联合口服氯雷他定治疗过敏性鼻炎的临床疗效。方法选择医院收治的120例过敏性鼻炎患者,随机分为两组,观察组采用鼻炎脱敏方雾化吸入联合口服氯雷他定治疗,对照组仅口服氯雷他定治疗,对比两组治疗后症状改善、炎症反应以及并发症等情况。结果观察组总有效率为96.7%,显著高于对照组的86.7%(P<0.05);治疗后,观察组鼻痒、打喷嚏、鼻塞、流涕评分及症状总分均显著低于对照组(P<0.05),IL-4、IL-10、Ig E水平均显著低于对照组,而IL-12、IFN-γ均显著高于对照组(P<0.05)。结论采用脱敏方雾化吸入联合口服氯雷他定治疗过敏性鼻炎,可更有效改善患者临床症状,减轻炎症反应,减少并发症发生,效果确切。Objective To explore the effects of rhinitis desensitization prescription combined with loratadine in the treatment of allergic rhinitis. Methods A total of 120 patients with allergic rhinitis to receive treatment in our hospital were selected and randomly divided into an observation group and a control group. The observation group was treated with rhinitis desensitization prescription atomization inhalation combined with oral administration of loratadine and the control group only with oral administration of loratadine. The post-treatment symptom improvement, inflammatory response and complications between the two groups were compared. Results The overall response rate（ORR） in the observation group was 96.7%, which was significantly higher than that in the control group of 86.7%（P 〈 0.05）; after the treatment, the nasal itching, sneezing, nasal congestion and running nose scores and total symptom scores in the observation group were much lower than those in the control group（P 〈 0.05）, and IL-4, IL-10 and Ig E levels were much lower than those in the control group while IL-12 and IFN-γ were significantly higher than those in the control group（P 〈 0.05）. Conclusion Rhinitis desensitization prescription atomization inhalation combined with oral administration of loratadine can improve the clinical symptoms among patients more effectively, reduce the inflammation and lower the incidence of complications, and has accurate effects in the treatment of allergic rhinitis.

关 键 词：鼻炎脱敏方 雾化吸入 氯雷他定 过敏性鼻炎 疗效 

分 类 号：R765[医药卫生—耳鼻咽喉科]