CaO-P_2O_5-SiO_2-SrO-ZrO_2生物玻璃的溶解性和生物活性  

Solubility and bioactivity of gel-derived CaO-P_2O_5-SiO_2-SrO-ZrO_2 bioglasses

作　　者：袁建伟 詹振翔 刘立宏[2] 肖涛[2] 雷霆[1] 

机构地区：[1]中南大学粉末冶金国家重点实验室,长沙410083 [2]中南大学湘雅二医院,长沙410011

出　　处：《粉末冶金材料科学与工程》2017年第6期774-782,共9页Materials Science and Engineering of Powder Metallurgy

基　　金：国家863项目SS2015AA032101

摘　　要：以氯氧化锆作为氧化锆的前驱体,取代等量的氧化钙,采用溶胶-凝胶法制备二氧化锆质量分数分别为5%、8%和11%的含锆生物玻璃(30-x)CaO-SiO_2-P_2O_5-Sr O-xZrO_2(BG-Zr),研究不同氧化锆含量对生物玻璃的溶解性和生物活性的改性。差热分析(TG/DSC)和X射线衍射(XRD)分析表明,加入ZrO_2可提高生物玻璃的结晶化转变温度并弱化其结晶趋势。Tris缓冲溶液和模拟体液(SBF)中的浸泡实验表明,与未改性生物玻璃相比,含锆生物玻璃表现出更缓慢的溶解速率和较低的羟基磷灰石形成能力,这一结果与其结构的稳定性和缓慢的溶解速率相关。Zr-incorporated CaO-P2O5-SiO2-SrO-ZrO2（BG-Zr） bioglasses were prepared through sol-gel process by adding zirconium oxychloride to the synthesis batch as zirconia precursor. The addition mass fraction of ZrO2 is 5%, 8% and 11%, respectively, to replace the same quality of CaO. The effects of ZrO2 on the solubility and bioactivity of BG-Zr were investigated. The differential thermal analysis （TG/DSC） and X-ray diffraction （XRD） indicate that the addition of ZrO2 to the base glass composition can increase its crystallization temperature and weaken the crystallization tendency. The tests in hydroxymethyl aminomethane （Tris） buffer and simulated body fluid （SBF） show that BG-Zr glasses exhibit lower dissolution rate and lower rate of apatite formation compared to the base glass, which is likely associated with their structure stabilization and lower solubility.

关 键 词：生物活性 ZRO2 溶胶-凝胶 溶解性 磷灰石 模拟体液 

分 类 号：TG-139[金属学及工艺]