广西两市2014—2015年新入组抗艾滋病病毒治疗者合并HBV、HCV感染的流行病学研究  

The epidemiology of co-infection with HBV and/or HCV among individuals who were newly recruited for anti-HIV therapy in two cities of Guangxi between 2014 and 2015

作　　者：王学燕[1,2] 张振开 韦兴强 陈钦艳[1,2] 周芸[3] 杨庆利 王超[1,2] 李开文[1,2] 胡莉萍 

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028 [2]广西病毒性肝炎防治研究重点实验室,广西南宁530028 [3]桂林市疾病预防控制中心,广西桂林541001 [4]河池市疾病预防控制中心,广西河池547000

出　　处：《应用预防医学》2017年第6期439-444,共6页Applied Preventive Medicine

基　　金：广西医药卫生计划课题(合同号Z20170144)

摘　　要：目的了解桂林、河池两市2014—2015年新入组抗艾滋病病毒治疗者合并感染乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)的流行病学特征,为有效开展艾滋病抗病毒治疗提供科学依据。方法采用描述性流行病学方法,分析广西桂林、河池市2014—2015年新入组艾滋病抗病毒治疗的艾滋病患者病例资料。病例个案资料来源于"艾滋病综合防治信息系统"的治疗信息数据库。结果广西桂林、河池两市2014—2015年新收治2 543例患者进行艾滋病抗病毒治疗。新入组治疗的艾滋病患者合并HBV、HCV的感染率分别为14.14%和2.96%,HIV+HBV+HCV三重感染率为0.53%。壮族、初中文化程度者HIV+HBV双重感染率较高,初中文化程度者HIV+HBV+HCV三重感染率也较高。HIV+HBV双重感染率为男性高于女性;10~40岁年龄组高于40岁以上年龄组;HIV传播途径为输血及血制品者高于其它传播途径者。HIV+HCV、HIV+HBV+HCV感染率也以10~40岁年龄组高于40岁以上年龄组。合并HBV、HCV、HBV+HCV感染的患者,其ALT水平显著高于单纯HIV感染者,差异有统计学意义(χ2=45.795,P=0.000)。结论桂林、河池两市艾滋病患者合并HBV、HCV感染较为常见,合并感染HBV和(或)HCV的艾滋病患者肝功能受损较重,提示抗HIV治疗时应加强监测,以减少肝脏损害。Objectives To understand the epidemiology of co-infection with HBV and/or HCV among individuals who were recruited for anti-HIV therapy in Guilin and Hechi City between 2014 and 2015 and provide scientific basis for effective anti-HIV therapy. Methods Data of HIV positive individuals who were newly recruited for anti-HIV therapy in Guilin and Hechi City between 2014 and 2015 were analyzed using descriptive epidemiological methods. Results The total number of 2 543 individuals was newly recruited for anti-HIV therapy between 2014 and 2015 in the two cities. The prevalence of HIV+HBV, HIV+HCV co-infection and HIV+HBV+HCV triple infection was 14.14%, 2.96% and 0.53%, respectively. The rate of co-infection or triple infection was higher in Zhuang minority or those with education of junior high school. The prevalence of HIV + HBV coinfection in male was higher than in female. The prevalence of HIV+HBV co-infection and HIV+HBV+HCV triple infection were all higher in the age group of10-40 than in those with 40 years old. The prevalence of HIV+HBV, HIV+HCV co-infection and HIV+HBV+HCV triple infection was higher in those with HIV infection route of transfusion and blood products than in those with other infection route. The abnormal rate of alanine aminotransferase(ALT) in the patients co-infection with HBV and/or HCV was higher than that of HIV mono-infection group(χ2= 45.795, P = 0.000). Conclusions HIV co-infection with HBV and/or HCV is common in Guilin and Hechi City. Co-infection with HBV and/or HCV is associated with severely liver damage, suggesting that enhanced monitoring should be taken during anti-HIV therapy for reducing the damage of the liver.

关 键 词：艾滋病 HIV HBV HCV 合并感染 流行病学 

分 类 号：R512.911[医药卫生—内科学]